Skip to main content

Research Repository

Advanced Search

Regional Brain Correlates of Beta Bursts in Health and Psychosis: A Concurrent Electroencephalography and Functional Magnetic Resonance Imaging Study

Briley, Paul M; Liddle, Elizabeth B.; Simmonite, Molly; Jansen, Marije; White, Thomas P; Balain, Vijender; Palaniyappan, Lena; Bowtell, Richard; Mullinger, Karen J.; Liddle, Peter F.

Authors

Paul M Briley

Molly Simmonite

Marije Jansen

Thomas P White

Vijender Balain

Lena Palaniyappan

Peter F. Liddle



Abstract

Background: There is emerging evidence for abnormal beta oscillations in psychosis. Beta-oscillations are likely to play a key role in the coordination of sensorimotor information, crucial to healthy mental function. Growing evidence suggests that beta oscillations typically manifest as transient “beta-bursts” that increase in probability following a motor response, observable as Post-Movement Beta Rebound (PMBR). Evidence indicates that PMBR is attenuated in psychosis, with greater attenuation associated with greater symptom severity and impairment. Delineating the functional role of beta-bursts may therefore be key to understanding the mechanisms underlying persistent psychotic illness.

Methods: We used concurrent EEG and fMRI to identify BOLD correlates of beta-bursts during the N-back working memory task and intervening rest periods in healthy participants (N = 30) and patients with psychosis (N = 48).

Results: During both task-blocks and intervening rest periods, beta-bursts phasically activated regions implicated in task-relevant content, while suppressing currently tonically active regions. Patients showed attenuated PMBR that was associated with persisting Disorganisation symptoms, as well as impairments in cognition and role function. Patients also showed greater task-related reductions in overall beta-burst rate, and greater, more extensive, beta-burst-related BOLD activation.

Conclusions: Our evidence supports a model in which beta-bursts reactivate latently maintained sensorimotor information and are dysregulated and inefficient in psychosis. We propose that abnormalities in the mechanisms by which beta-bursts coordinate reactivation of contextually appropriate content can manifest as Disorganisation, working memory deficits and inaccurate forward models, and may underlie a “core deficit” associated with persisting symptoms and impairment.

Citation

Briley, P. M., Liddle, E. B., Simmonite, M., Jansen, M., White, T. P., Balain, V., …Liddle, P. F. (2021). Regional Brain Correlates of Beta Bursts in Health and Psychosis: A Concurrent Electroencephalography and Functional Magnetic Resonance Imaging Study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 6(12), 1145-1156. https://doi.org/10.1016/j.bpsc.2020.10.018

Journal Article Type Article
Acceptance Date Oct 22, 2020
Online Publication Date Nov 5, 2020
Publication Date 2021-12
Deposit Date Nov 17, 2020
Publicly Available Date Jan 26, 2021
Journal Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Print ISSN 2451-9022
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 6
Issue 12
Pages 1145-1156
DOI https://doi.org/10.1016/j.bpsc.2020.10.018
Keywords Psychosis; concurrent EEG/fMRI; transient beta oscillations; post-motor beta rebound; working memory; persisting psychotic illness
Public URL https://nottingham-repository.worktribe.com/output/5020078
Publisher URL https://www.sciencedirect.com/science/article/pii/S2451902220303220

Files







You might also like



Downloadable Citations