Effects of dorsal hippocampal damage on conditioning and conditioned-response timing: a pooled analysis

Tam, Shu K.E.; Jennings, D�mhnall J.; Bonardi, Charlotte

Abstract

Behavioral findings suggest that the dorsal hippocampus (DHPC) plays a role in timing of appetitive conditioned responding. The present article explored the relationship between the extent of DHPC damage and timing ability, in a pooled analysis of three published studies from our laboratory. Initial analyses of variance confirmed our previous reports that DHPC damage reduced peak time (a measure of timing accuracy). However, the spread (a measure of timing precision) was unchanged, such that the coefficient of variation (spread/peak time) was significantly larger in DHPC-lesioned animals. This implies that, in addition to the well-established effect of DHPC lesions on timing accuracy, DHPC damage produced a deficit in precision of timing. To complement this analysis, different generalized linear mixed-effects models (GLMMs) were performed on the combined dataset, to examine which combinations of the different behavioral measures of timing were the best predictors of the degree of hippocampal damage. The results from the GLMM analysis suggested that the greater the DHPC damage, the greater the absolute difference between the observed peak time and reinforced duration. Nevertheless, this systematic relationship between damage and performance was not specific to the temporal domain: paradoxically the greater the damage the greater the magnitude of peak responding. We discuss these lesion effects in terms of scalar timing theory.

Citation

Tam, S. K., Jennings, D. J., & Bonardi, C. (2015). Effects of dorsal hippocampal damage on conditioning and conditioned-response timing: a pooled analysis. Hippocampus, 25(4), https://doi.org/10.1002/hipo.22381

• Journal Article Type: Article
• Acceptance Date: Oct 14, 2014
• Online Publication Date: Oct 31, 2014
• Publication Date: Apr 1, 2015
• Deposit Date: Oct 2, 2017
• Publicly Available Date: Oct 2, 2017
• Journal: Hippocampus
• Print ISSN: 1050-9631
• Electronic ISSN: 1098-1063
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 25
• Issue: 4
• DOI: https://doi.org/10.1002/hipo.22381
• Keywords: pavlovian conditioning; interval timing; peak procedure
• Public URL: https://nottingham-repository.worktribe.com/output/984428
• Publisher URL: http://onlinelibrary.wiley.com/doi/10.1002/hipo.22381/abstract
• Additional Information: This is the peer reviewed version of the following article: Tam, S. K.E., Jennings, D. J. and Bonardi, C. (2015), Effects of dorsal hippocampal damage on conditioning and conditioned-response timing: A pooled analysis. Hippocampus, 25: 444–459, which has been published in final form at http://dx.doi.org/10.1002/hipo.22381. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.