Honglei Sun
Highly pathogenic avian influenza H5N6 viruses exhibit enhanced affinity for human type sialic acid receptor and in-contact transmission in model ferrets
Sun, Honglei; Pu, Juan; Wei, Yandi; Sun, Yipeng; Hu, Jiao; Liu, Litao; Xu, Guanlong; Gao, Weihua; Li, Chong; Zhang, Xuxiao; Huang, Yinhua; Chang, Kin-Chow; Liu, Xiufan; Liu, Jinhua
Authors
Juan Pu
Yandi Wei
Yipeng Sun
Jiao Hu
Litao Liu
Guanlong Xu
Weihua Gao
Chong Li
Xuxiao Zhang
Yinhua Huang
Professor KIN-CHOW CHANG KIN-CHOW.CHANG@NOTTINGHAM.AC.UK
PROFESSOR OF VETERINARY MOLECULAR MEDICINE
Xiufan Liu
Jinhua Liu
Abstract
Since May 2014, highly pathogenic avian influenza H5N6 virus has been reported to cause six severe human infections three of which were fatal. The biological properties of this subtype, in particular its relative pathogenicity and transmissibility in mammals, are not known. We characterized the virus receptor-binding affinity, pathogenicity, and transmissibility in mice and ferrets of four H5N6 isolates derived from waterfowl in China from 2013-2014. All four H5N6 viruses have acquired a binding affinity for human-like SA alpha 2,6Gal-linked receptor to be able to attach to human tracheal epithelial and alveolar cells. The emergent H5N6 viruses, which share high sequence similarity with the human isolate A/Guangzhou/39715/2014 (H5N6), were fully infective and highly transmissible by direct contact in ferrets but showed less-severe pathogenicity than the parental H5N1 virus. The present results highlight the threat of emergent H5N6 viruses to poultry and human health and the need to closely track their continual adaptation in humans.
Citation
Sun, H., Pu, J., Wei, Y., Sun, Y., Hu, J., Liu, L., Xu, G., Gao, W., Li, C., Zhang, X., Huang, Y., Chang, K.-C., Liu, X., & Liu, J. (2016). Highly pathogenic avian influenza H5N6 viruses exhibit enhanced affinity for human type sialic acid receptor and in-contact transmission in model ferrets. Journal of Virology, 90(14), https://doi.org/10.1128/JVI.00127-16
Journal Article Type | Article |
---|---|
Acceptance Date | Apr 21, 2016 |
Online Publication Date | Apr 27, 2016 |
Publication Date | Jul 1, 2016 |
Deposit Date | Nov 7, 2016 |
Publicly Available Date | Nov 7, 2016 |
Journal | Journal of Virology |
Print ISSN | 0022-538X |
Electronic ISSN | 1098-5514 |
Publisher | American Society for Microbiology |
Peer Reviewed | Peer Reviewed |
Volume | 90 |
Issue | 14 |
DOI | https://doi.org/10.1128/JVI.00127-16 |
Public URL | https://nottingham-repository.worktribe.com/output/976311 |
Publisher URL | http://jvi.asm.org/content/90/14/6235.long |
Contract Date | Nov 7, 2016 |
Files
J Virol -2016-Sun-6235-43.pdf
(2.5 Mb)
PDF
Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf
You might also like
Airborne transmission of human-isolated avian H3N8 influenza virus between ferrets
(2023)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2025
Advanced Search