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Highly pathogenic avian influenza H5N6 viruses exhibit enhanced affinity for human type sialic acid receptor and in-contact transmission in model ferrets

Sun, Honglei; Pu, Juan; Wei, Yandi; Sun, Yipeng; Hu, Jiao; Liu, Litao; Xu, Guanlong; Gao, Weihua; Li, Chong; Zhang, Xuxiao; Huang, Yinhua; Chang, Kin-Chow; Liu, Xiufan; Liu, Jinhua

Authors

Honglei Sun

Juan Pu

Yandi Wei

Yipeng Sun

Jiao Hu

Litao Liu

Guanlong Xu

Weihua Gao

Chong Li

Xuxiao Zhang

Yinhua Huang

KIN-CHOW CHANG kin-chow.chang@nottingham.ac.uk
Professor of Veterinary Molecular Medicine

Xiufan Liu

Jinhua Liu



Abstract

Since May 2014, highly pathogenic avian influenza H5N6 virus has been reported to cause six severe human infections three of which were fatal. The biological properties of this subtype, in particular its relative pathogenicity and transmissibility in mammals, are not known. We characterized the virus receptor-binding affinity, pathogenicity, and transmissibility in mice and ferrets of four H5N6 isolates derived from waterfowl in China from 2013-2014. All four H5N6 viruses have acquired a binding affinity for human-like SA alpha 2,6Gal-linked receptor to be able to attach to human tracheal epithelial and alveolar cells. The emergent H5N6 viruses, which share high sequence similarity with the human isolate A/Guangzhou/39715/2014 (H5N6), were fully infective and highly transmissible by direct contact in ferrets but showed less-severe pathogenicity than the parental H5N1 virus. The present results highlight the threat of emergent H5N6 viruses to poultry and human health and the need to closely track their continual adaptation in humans.

Citation

Sun, H., Pu, J., Wei, Y., Sun, Y., Hu, J., Liu, L., …Liu, J. (2016). Highly pathogenic avian influenza H5N6 viruses exhibit enhanced affinity for human type sialic acid receptor and in-contact transmission in model ferrets. Journal of Virology, 90(14), https://doi.org/10.1128/JVI.00127-16

Journal Article Type Article
Acceptance Date Apr 21, 2016
Online Publication Date Apr 27, 2016
Publication Date Jul 1, 2016
Deposit Date Nov 7, 2016
Publicly Available Date Nov 7, 2016
Journal Journal of Virology
Print ISSN 0022-538X
Electronic ISSN 1098-5514
Publisher American Society for Microbiology
Peer Reviewed Peer Reviewed
Volume 90
Issue 14
DOI https://doi.org/10.1128/JVI.00127-16
Public URL http://eprints.nottingham.ac.uk/id/eprint/38539
Publisher URL http://jvi.asm.org/content/90/14/6235.long
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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J Virol -2016-Sun-6235-43.pdf (2.5 Mb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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