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Psychological morbidity and health related quality of life after injury: multicentre cohort study

Kendrick, Denise; Kellezi, Blerina; Coupland, Carol; Maula, A.; Beckett, Kate; Morriss, Richard K.; Joseph, Stephen; Barnes, Jo; Sleney, Jude; Christie, Nicola


Professor of Primary Care Research

Blerina Kellezi

Professor of Medical Statistics

A. Maula

Kate Beckett

Richard K. Morriss

Jo Barnes

Jude Sleney

Nicola Christie


Purpose: To demonstrate the impact of psychological morbidity one month post-injury on subsequent post-injury quality of life (HRQoL) in a general injury population in the UK to inform development of trauma care and rehabilitation services.

Methods: Multicentre cohort study of 16-70 year olds admitted to 4 UK hospitals following injury. Psychological morbidity and HRQoL (EQ-5D-3L) were measured at recruitment and one, two, four and 12 months post-injury. A reduction in EQ-5D compared to retrospectively assessed pre-injury levels of at least 0.074 was taken as the minimal important difference (MID). Multilevel logistic regression explored relationships between psychological morbidity one month post-injury and MID in HRQoL over the 12 months after injury.

Results: 668 adults participated. Follow-up rates were 77% (1 month) and 63% (12 months). Substantial reductions in HRQoL were seen; 93% reported a MID at one month and 58% at 12 months. Problems with pain, mobility and usual activities were commonly reported at each time point. Depression and anxiety scores one month post-injury were independently associated with subsequent MID in HRQoL. The relationship between depression and HRQoL was partly explained by anxiety and to a lesser extent by pain and social functioning. The relationship between anxiety and HRQoL was not explained by factors measured in our study.

Conclusions: Hospitalised injuries result in substantial reductions in HRQoL up to 12 months later. Depression and anxiety early in the recovery period are independently associated with lower HRQoL. Identifying and managing these problems, ensuring adequate pain control and facilitating social functioning are key elements in improving HRQoL post-injury.


Kendrick, D., Kellezi, B., Coupland, C., Maula, A., Beckett, K., Morriss, R. K., …Christie, N. (2017). Psychological morbidity and health related quality of life after injury: multicentre cohort study. Quality of Life Research, 26(5), 1233-1250.

Journal Article Type Article
Acceptance Date Oct 13, 2016
Online Publication Date Oct 26, 2016
Publication Date May 1, 2017
Deposit Date Nov 2, 2016
Publicly Available Date Nov 2, 2016
Journal Quality of Life Research
Print ISSN 0962-9343
Electronic ISSN 1573-2649
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 26
Issue 5
Pages 1233-1250
Keywords Unintentional injury; quality of life; depression; anxiety; cohort study
Public URL
Publisher URL


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