Atypical processing of gaze cues and faces explains comorbidity between autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD)

Groom, Madeleine J.; Kochhar, Puja; Hamilton, Antonia; Liddle, Elizabeth B.; Simeou, Marina; Hollis, Chris

doi:10.1007/s10803-017-3078-4

Atypical processing of gaze cues and faces explains comorbidity between autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD)

Groom, Madeleine J.; Kochhar, Puja; Hamilton, Antonia; Liddle, Elizabeth B.; Simeou, Marina; Hollis, Chris

Authors

Dr MADDIE GROOM maddie.groom@nottingham.ac.uk
Associate Professor

Puja Kochhar

Antonia Hamilton

Elizabeth B. Liddle

Marina Simeou

CHRIS HOLLIS chris.hollis@nottingham.ac.uk
Professor of Child and Adolescent Psychiatry and Digital Mental Health

Abstract

This study investigated the neurobiological basis of comorbidity between autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). We compared children with ASD, ADHD or ADHD+ASD and typically developing controls (CTRL) on behavioural and electrophysiological correlates of gaze cue and face processing. We measured effects of ASD, ADHD and their interaction on the EDAN, an ERP marker of orienting visual attention towards a spatially cued location and the N170, a right-hemisphere lateralised ERP linked to face processing. We identified atypical gaze cue and face processing in children with ASD and ADHD+ASD compared with the ADHD and CTRL groups. The findings indicate a neurobiological basis for the presence of comorbid ASD symptoms in ADHD. Further research using larger samples is needed.

Citation

Groom, M. J., Kochhar, P., Hamilton, A., Liddle, E. B., Simeou, M., & Hollis, C. (2017). Atypical processing of gaze cues and faces explains comorbidity between autism spectrum disorder (ASD) and attention deficit/hyperactivity disorder (ADHD). Journal of Autism and Developmental Disorders, 47(5), https://doi.org/10.1007/s10803-017-3078-4

Journal Article Type	Article
Acceptance Date	Feb 17, 2017
Online Publication Date	Mar 2, 2017
Publication Date	May 1, 2017
Deposit Date	Mar 10, 2017
Publicly Available Date	Mar 10, 2017
Journal	Journal of Autism and Developmental Disorders
Print ISSN	0162-3257
Electronic ISSN	1573-3432
Publisher	Springer Verlag
Peer Reviewed	Peer Reviewed
Volume	47
Issue	5
DOI	https://doi.org/10.1007/s10803-017-3078-4
Keywords	ASD; ADHD; ERPs; Comorbidity; Gaze cueing; Face processing
Public URL	https://nottingham-repository.worktribe.com/output/969406
Publisher URL	http://link.springer.com/article/10.1007%2Fs10803-017-3078-4