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Re-evaluation of the regulation of omeprazole in racehorses: an evidence-based approach

Viljanto, Marjaana; Hillyer, Lynn; Hincks, Pamela; Pearce, Clive; Paine, Stuart

Authors

Marjaana Viljanto marjaana.viljanto@lgcgroup.com

Lynn Hillyer lynn.hillyer@turfclub.ie

Pamela Hincks

Clive Pearce



Abstract

Medication and doping control has been established in horseracing to ensure the integrity of the sport and the welfare of the horses. This ensures that horses do not compete under the influence of any drugs, including omeprazole, a therapeutic medication used to treat equine gastric ulcer syndrome. In this study, pharmacokinetic data were produced in equine plasma and urine following an oral administration of 4 mg/kg of generic buffered formulation of omeprazole to six Thoroughbred horses in five daily doses to determine an appropriate screening limit and detection time in equine plasma and to assess whether the current detection time of 72 hours in equine urine would be applicable when an alternative omeprazole product is administered. Cmax of 436 – 2432 ng/mL and AUC0-tau of 1476 – 4371 ng.hr/mL were obtained for plasma and indicated, in conjunction with other published oral omeprazole studies, that an appropriate plasma screening limit would be 500 pg/mL with a detection time of 48 hours. Urine analysis showed that omeprazole could be detected for up to 25 hours above the previously established urine screening limit of 500 pg/mL, and thus, indicated that the detection time advice could be potentially reduced from 72 hours to 48 hours to allow more comprehensive treatment of gastric lesions.

Journal Article Type Article
Publication Date Jun 1, 2018
Journal Journal of Veterinary Pharmacology and Therapeutics
Print ISSN 0140-7783
Electronic ISSN 1365-2885
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 41
Issue 3
APA6 Citation Viljanto, M., Hillyer, L., Hincks, P., Pearce, C., & Paine, S. (2018). Re-evaluation of the regulation of omeprazole in racehorses: an evidence-based approach. Journal of Veterinary Pharmacology and Therapeutics, 41(3), https://doi.org/10.1111/jvp.12491
DOI https://doi.org/10.1111/jvp.12491
Keywords detection time; medication control; omeprazole; pharmacokinetics; screening limit
Publisher URL https://onlinelibrary.wiley.com/doi/abs/10.1111/jvp.12491
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information This is the peer reviewed version of the following article: Viljanto M, Hillyer L, Hincks P, Pearce C, Paine SW. Re-evaluation of the regulation of omeprazole in racehorses: An evidence-based approach. J vet Pharmacol Therap. 2018; 41,3:469-497. https://doi.org/10.1111/jvp.12491, which has been published in final form at https:/doi.org/10.1111/jvp.12491. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

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Omeprazole paper.pdf (743 Kb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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