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Cognitive neuroscience using wearable magnetometer arrays: non-invasive assessment of language function

Tierney, Tim M.; Holmes, Niall; Meyer, Sofie S.; Boto, Elena; Roberts, Gillian; Leggett, James; Buck, Sarah; Duque-Muñoz, Leonardo; Litvak, Vladimir; Bestmann, Sven; Baldeweg, Torsten; Bowtell, Richard W.; Brookes, Matthew J.; Barnes, Gareth R.

Authors

Tim M. Tierney

Niall Holmes

Sofie S. Meyer

Elena Boto elena.boto@nottingham.ac.uk

Gillian Roberts gillian.roberts@nottingham.ac.uk

James Leggett

Sarah Buck

Leonardo Duque-Muñoz

Vladimir Litvak

Sven Bestmann

Torsten Baldeweg

Richard W. Bowtell richard.bowtell@nottingham.ac.uk

Matthew J. Brookes matthew.brookes@nottingham.ac.uk

Gareth R. Barnes

Abstract

Recent work has demonstrated that Optically Pumped Magnetometers (OPMs) can be utilised to create a wearable Magnetoencephalography (MEG) system that is motion robust. In this study, we use this system to map eloquent cortex using a clinically validated language lateralisation paradigm (covert verb generation: 120 trials, ~10 minutes total duration) in healthy adults (n=3). We show that it is possible to lateralise and localise language function on a case by case basis using this system. Specifically, we show that at a sensor and source level we can reliably detect a lateralising beta band (15-30Hz) desynchronization in all subjects. This is the first demonstration of studying human cognition with OPMs and not only highlights this technology’s utility as tool for (developmental) cognitive neuroscience but also its potential to contribute to surgical planning via mapping of eloquent cortex, especially in young children.

Journal Article Type Article
Publication Date Nov 1, 2018
Journal NeuroImage
Print ISSN 1053-8119
Electronic ISSN 1095-9572
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 181
Pages 513-520
Institution Citation Tierney, T. M., Holmes, N., Meyer, S. S., Boto, E., Roberts, G., Leggett, J., …Barnes, G. R. (2018). Cognitive neuroscience using wearable magnetometer arrays: non-invasive assessment of language function. NeuroImage, 181, (513-520). doi:10.1016/j.neuroimage.2018.07.035. ISSN 1053-8119
DOI https://doi.org/10.1016/j.neuroimage.2018.07.035
Keywords Optically pumped magnetometers; Language; MEG
Publisher URL https://www.sciencedirect.com/science/article/pii/S1053811918306505
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
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