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TMS over the supramarginal gyrus delays selection of appropriate grasp orientation during reaching and grasping tools for use

McDowell, Tomás; Holmes, Nicholas P.; Sunderland, Alan; Schürmann, Martin

Authors

Tomás McDowell

Alan Sunderland

MARTIN SCHUERMANN martin.schuermann@nottingham.ac.uk
Associate Professor & Reader in Cognitive Neuroscience



Abstract

Tool use, a ubiquitous part of human behaviour, requires manipulation control and knowledge of tool purpose. Neuroimaging and neuropsychological research posit that these two processes are supported by separate brain regions, ventral premotor and inferior parietal for manipulation control, and posterior middle temporal cortex for tool knowledge, lateralised to the left hemisphere. Action plans for tool use need to integrate these two separate processes, which is likely supported by the left supramarginal gyrus (SMG). However, whether this integration occurs during action execution is not known. To clarify the role of the SMG we conducted two experiments in which healthy participants reached to grasp everyday tools with the explicit instruction to use them directly following their grasp. To study the integration of manipulation control and tool knowledge within a narrow time window we mechanically perturbed the orientation of the tool to force participants to correct grasp orientation 'on-line' during the reaching movement. In experiment 1, twenty healthy participants reached with their left hand to grasp a tool. Double-pulse transcranial magnetic stimulation (TMS) was applied, in different blocks over left or right SMG at the onset of perturbation. Kinematic data revealed delayed and erroneous online correction after TMS over left and right SMG. In Experiment 2 twelve participants reached, in different blocks, with their left or right hand and TMS was applied over SMG ipsilateral to the reaching hand. A similar effect on correction was observed for ipsilateral stimulation when reaching with the left and right hands, and no effect of or interaction with hemisphere was observed. Our findings implicate a bilateral role of the SMG in correcting movements and selection of appropriate grasp orientation during reaching to grasp tools for use.

Citation

McDowell, T., Holmes, N. P., Sunderland, A., & Schürmann, M. (2018). TMS over the supramarginal gyrus delays selection of appropriate grasp orientation during reaching and grasping tools for use. Cortex, 103, 117-129. doi:10.1016/j.cortex.2018.03.002

Journal Article Type Article
Acceptance Date Mar 1, 2018
Online Publication Date Mar 9, 2018
Publication Date Jun 30, 2018
Deposit Date Mar 14, 2018
Publicly Available Date Mar 10, 2019
Journal Cortex
Print ISSN 0010-9452
Electronic ISSN 1973-8102
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 103
Pages 117-129
DOI https://doi.org/10.1016/j.cortex.2018.03.002
Keywords Tool use; Visuomotor Control; Grasp Orientation; TMS; SMG
Public URL http://eprints.nottingham.ac.uk/id/eprint/50435
Publisher URL https://www.sciencedirect.com/science/article/pii/S0010945218300716
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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