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Synchronization of fronto-parietal beta and theta networks as a signature of visual awareness in neglect

Yordanova, Juliana; Kolev, Vasil; Verleger, Rolf; Heide, Wolfgang; Grumbt, Michael; Schürmann, Martin

Authors

Juliana Yordanova

Vasil Kolev

Rolf Verleger

Wolfgang Heide

Michael Grumbt

Martin Schürmann



Abstract

In the neglect syndrome, the perceptual deficit for contra-lesional hemi-space is increasingly viewed as a dysfunction of fronto-parietal cortical networks, the disruption of which has been described in neuroanatomical and hemodynamic studies. Here we exploit the superior temporal resolution of electroencephalography (EEG) to study dynamic transient connectivity of fronto-parietal circuits at early stages of visual perception in neglect. As reflected by inter-regional phase synchronization in a full-field attention task, two functionally distinct fronto-parietal networks, in beta (15–25 Hz) and theta (4–8 Hz) frequency bands, were related to stimulus discrimination within the first 200 ms of visual processing. Neglect pathology was specifically associated with significant suppressions of both beta and theta networks engaging right parietal regions. These connectivity abnormalities occurred in a pattern that was distinctly different from what was observed in right-hemisphere lesion patients without neglect. Also, both beta and theta abnormalities contributed additively to visual awareness decrease, quantified in the Behavioural Inattention Test. These results provide evidence for the impairment of fast dynamic fronto-parietal interactions during early stages of visual processing in neglect pathology. Also, they reveal that different modes of fronto-parietal dysfunction contribute independently to deficits in visual awareness at the behavioural level.

Journal Article Type Article
Publication Date Feb 1, 2017
Journal NeuroImage
Print ISSN 1053-8119
Electronic ISSN 1095-9572
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 146
APA6 Citation Yordanova, J., Kolev, V., Verleger, R., Heide, W., Grumbt, M., & Schürmann, M. (2017). Synchronization of fronto-parietal beta and theta networks as a signature of visual awareness in neglect. NeuroImage, 146, doi:10.1016/j.neuroimage.2016.11.013
DOI https://doi.org/10.1016/j.neuroimage.2016.11.013
Keywords Neglect, Sychronization, EEG, Connectivity, Theta
Publisher URL http://www.sciencedirect.com/science/article/pii/S1053811916306188
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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