Travis E. Baker
Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence
Baker, Travis E.; Castellanos-Ryan, Natalie; Schumann, Gunter; Cattrell, Anna; Flor, Herta; Nees, Frauke; Banaschewski, Tobias; Bokde, Arun L.W.; Whelan, Rob; Buechel, Christian; Bromberg, Uli; Orfanos, Dimitri Papadopoulos; Gallinat, Jürgen; Garavan, Hugh; Heinz, Andreas; Walter, Henrik; Brühl, Rüdiger; Gowland, Penny A.; Paus, Tomáš; Poustka, Luise; Martinot, Jean-Luc; Lemaitre, Hervé; Artiges, Eric; Martinot, Marie-Laure Paillère; Smolka, Michael N.; Conrod, Patricia J.
Authors
Natalie Castellanos-Ryan
Gunter Schumann
Anna Cattrell
Herta Flor
Frauke Nees
Tobias Banaschewski
Arun L.W. Bokde
Rob Whelan
Christian Buechel
Uli Bromberg
Dimitri Papadopoulos Orfanos
Jürgen Gallinat
Hugh Garavan
Andreas Heinz
Henrik Walter
Rüdiger Brühl
Professor PENNY GOWLAND PENNY.GOWLAND@NOTTINGHAM.AC.UK
Professor of Physics
Tomáš Paus
Luise Poustka
Jean-Luc Martinot
Hervé Lemaitre
Eric Artiges
Marie-Laure Paillère Martinot
Michael N. Smolka
Patricia J. Conrod
Abstract
Background: Abnormalities in reward circuit function are considered a core feature of addiction. Yet, it is still largely unknown whether these abnormalities stem from chronic drug use, a genetic predisposition, or both.
Methods: In the present study, we investigated this issue using a large sample of adolescent children by applying structural equation modeling to examine the effects of several dopaminergic polymorphisms of the D1 and D2 receptor type on the reward function of the ventral striatum and orbital frontal cortex, and whether this relationship predicted the propensity to engage in early alcohol misuse behaviours at 14 years of age and again at 16 years of age.
Results: The results demonstrated a regional specificity with which the functional polymorphism rs686 of the DRD1 gene and Taq1A of the ANKK1 gene influenced medial and lateral orbital frontal cortex activation during reward anticipation, respectively. Importantly, our path model revealed a significant indirect relationship between the rs686 of the DRD1 gene and early onset of alcohol misuse through a medial orbital frontal cortex and the ventral striatum interaction.
Conclusions: These findings highlight the role of D1 and D2 in adjusting reward-related activations within the mesocorticolimbic circuitry, as well as in the susceptibility to early onset of alcohol misuse.
Citation
Baker, T. E., Castellanos-Ryan, N., Schumann, G., Cattrell, A., Flor, H., Nees, F., …Conrod, P. J. (2019). Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence. Psychological Medicine, 49(5), 801-810. https://doi.org/10.1017/S0033291718001459
Journal Article Type | Article |
---|---|
Acceptance Date | Apr 16, 2018 |
Online Publication Date | Jun 18, 2018 |
Publication Date | 2019-04 |
Deposit Date | Apr 18, 2018 |
Publicly Available Date | Dec 19, 2018 |
Journal | Psychological Medicine |
Print ISSN | 0033-2917 |
Electronic ISSN | 1469-8978 |
Publisher | Cambridge University Press |
Peer Reviewed | Peer Reviewed |
Volume | 49 |
Issue | 5 |
Pages | 801-810 |
DOI | https://doi.org/10.1017/S0033291718001459 |
Keywords | adolescence; dopamine D1/D2 receptor; ventral striatum; orbital frontal cortex; reward; addiction |
Public URL | https://nottingham-repository.worktribe.com/output/939352 |
Publisher URL | https://www.cambridge.org/core/journals/psychological-medicine/article/modulation-of-orbitofrontalstriatal-reward-activity-by-dopaminergic-functional-polymorphisms-contributes-to-a-predisposition-to-alcohol-misuse-in-early-adolescence/616F5E24313D3563B324 |
Contract Date | Apr 18, 2018 |
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