Early life incidence of gastrointestinal and respiratory infections in children with gastroschisis: a cohort study
Bannister, Jessica; Szatkowski, Lisa; Sharkey, Don; Tan, Shin; Fiaschi, Linda; Ban, Lu
Shin Tan Shin.Tan@nottingham.ac.uk
Objectives: Survival in infants with gastroschisis is increasing although little is known about early childhood morbidity. In the context of a hypothesised link between the gastrointestinal (GI) tract and immune function, this study explores rates of GI and respiratory infections in children with gastroschisis.
Methods: We conducted a population-based retrospective cohort study using data from the Health Improvement Network (THIN), a large database of UK primary care medical records. We identified children born from 1990 to 2013, and extracted follow-up data to their fifth birthday. We calculate incidence rates (IR) of GI and respiratory tract infections, overall and stratified by age, sex, socioeconomic status and gestational age at birth, and compared these between children with and without gastroschisis by calculating adjusted incidence rate ratios (aIRR).
Results: Children with gastroschisis had a 65% higher IR of GI infection compared to children without (aIRR 1.65, 95% CI 1.37-1.99, p
|Journal Article Type||Article|
|Journal||Journal of Pediatric Gastroenterology and Nutrition|
|Publisher||Lippincott, Williams & Wilkins|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Bannister, J., Szatkowski, L., Sharkey, D., Tan, S., Fiaschi, L., & Ban, L. (2018). Early life incidence of gastrointestinal and respiratory infections in children with gastroschisis: a cohort study. Journal of Pediatric Gastroenterology and Nutrition, 67(5), 580–585. doi:10.1097/MPG.0000000000002045|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf|
|Additional Information||This is not the final published version. The final published version Bannister, Jessica, Szatkowski, Lisa, Sharkey, Don, Tan, Shin, Fiaschi, Linda, Ban, Lu. Early life incidence of gastrointestinal and respiratory infections in children with gastroschisis: a cohort study. Journal of Pediatric Gastroenterology and Nutrition
is available at https://journals.lww.co...testinal_and.96797.aspx
Infections in children with gastroschisis - eprints.pdf
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf