Early life incidence of gastrointestinal and respiratory infections in children with gastroschisis: a cohort study

Bannister, Jessica; Szatkowski, Lisa; Sharkey, Don; Tan, Shin; Fiaschi, Linda; Ban, Lu

Abstract

Objectives: Survival in infants with gastroschisis is increasing although little is known about early childhood morbidity. In the context of a hypothesised link between the gastrointestinal (GI) tract and immune function, this study explores rates of GI and respiratory infections in children with gastroschisis.
Methods: We conducted a population-based retrospective cohort study using data from the Health Improvement Network (THIN), a large database of UK primary care medical records. We identified children born from 1990 to 2013, and extracted follow-up data to their fifth birthday. We calculate incidence rates (IR) of GI and respiratory tract infections, overall and stratified by age, sex, socioeconomic status and gestational age at birth, and compared these between children with and without gastroschisis by calculating adjusted incidence rate ratios (aIRR).
Results: Children with gastroschisis had a 65% higher IR of GI infection compared to children without (aIRR 1.65, 95% CI 1.37-1.99, p

• Journal Article Type: Article
• Acceptance Date: May 11, 2018
• Online Publication Date: May 30, 2018
• Publication Date: 2018-11
• Deposit Date: May 15, 2018
• Publicly Available Date: May 31, 2019
• Journal: Journal of Pediatric Gastroenterology and Nutrition
• Print ISSN: 0277-2116
• Electronic ISSN: 1536-4801
• Publisher: Lippincott, Williams & Wilkins
• Peer Reviewed: Peer Reviewed
• Volume: 67
• Issue: 5
• Pages: 580–585
• DOI: https://doi.org/10.1097/MPG.0000000000002045
• Public URL: https://nottingham-repository.worktribe.com/output/934476
• Publisher URL: https://journals.lww.com/jpgn/Abstract/publishahead/Early_Life_Incidence_of_Gastrointestinal_and.96797.aspx
• Additional Information: This is not the final published version. The final published version Bannister, Jessica, Szatkowski, Lisa, Sharkey, Don, Tan, Shin, Fiaschi, Linda, Ban, Lu. Early life incidence of gastrointestinal and respiratory infections in children with gastroschisis: a cohort study. Journal of Pediatric Gastroenterology and Nutrition; is available at https://journals.lww.com/jpgn/Abstract/publishahead/Early_Life_Incidence_of_Gastrointestinal_and.96797.aspx