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Early life incidence of gastrointestinal and respiratory infections in children with gastroschisis: a cohort study

Bannister, Jessica; Szatkowski, Lisa; Sharkey, Don; Tan, Shin; Fiaschi, Linda; Ban, Lu

Authors

Jessica Bannister

Lisa Szatkowski

Don Sharkey

Shin Tan Shin.Tan@nottingham.ac.uk

Linda Fiaschi

Lu Ban



Abstract

Objectives: Survival in infants with gastroschisis is increasing although little is known about early childhood morbidity. In the context of a hypothesised link between the gastrointestinal (GI) tract and immune function, this study explores rates of GI and respiratory infections in children with gastroschisis.
Methods: We conducted a population-based retrospective cohort study using data from the Health Improvement Network (THIN), a large database of UK primary care medical records. We identified children born from 1990 to 2013, and extracted follow-up data to their fifth birthday. We calculate incidence rates (IR) of GI and respiratory tract infections, overall and stratified by age, sex, socioeconomic status and gestational age at birth, and compared these between children with and without gastroschisis by calculating adjusted incidence rate ratios (aIRR).
Results: Children with gastroschisis had a 65% higher IR of GI infection compared to children without (aIRR 1.65, 95% CI 1.37-1.99, p

Journal Article Type Article
Publication Date 2018-11
Journal Journal of Pediatric Gastroenterology and Nutrition
Print ISSN 0277-2116
Electronic ISSN 1536-4801
Publisher Lippincott, Williams & Wilkins
Peer Reviewed Peer Reviewed
Volume 67
Issue 5
Pages 580–585
APA6 Citation Bannister, J., Szatkowski, L., Sharkey, D., Tan, S., Fiaschi, L., & Ban, L. (2018). Early life incidence of gastrointestinal and respiratory infections in children with gastroschisis: a cohort study. Journal of Pediatric Gastroenterology and Nutrition, 67(5), 580–585. doi:10.1097/MPG.0000000000002045
DOI https://doi.org/10.1097/MPG.0000000000002045
Publisher URL https://journals.lww.com/jpgn/Abstract/publishahead/Early_Life_Incidence_of_Gastrointestinal_and.96797.aspx
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information This is not the final published version. The final published version Bannister, Jessica, Szatkowski, Lisa, Sharkey, Don, Tan, Shin, Fiaschi, Linda, Ban, Lu. Early life incidence of gastrointestinal and respiratory infections in children with gastroschisis: a cohort study. Journal of Pediatric Gastroenterology and Nutrition
is available at https://journals.lww.co...testinal_and.96797.aspx

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Infections in children with gastroschisis - eprints.pdf (340 Kb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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