Skip to main content

Research Repository

Advanced Search

Early life incidence of gastrointestinal and respiratory infections in children with gastroschisis: a cohort study

Bannister, Jessica; Szatkowski, Lisa; Sharkey, Don; Tan, Shin; Fiaschi, Linda; Ban, Lu

Authors

Jessica Bannister

Profile Image

DON SHARKEY don.sharkey@nottingham.ac.uk
Clinical Associate Professor

Shin Tan

LINDA FIASCHI LINDA.FIASCHI@NOTTINGHAM.AC.UK
Senior Research Fellow in Health

Lu Ban



Abstract

Objectives: Survival in infants with gastroschisis is increasing although little is known about early childhood morbidity. In the context of a hypothesised link between the gastrointestinal (GI) tract and immune function, this study explores rates of GI and respiratory infections in children with gastroschisis.
Methods: We conducted a population-based retrospective cohort study using data from the Health Improvement Network (THIN), a large database of UK primary care medical records. We identified children born from 1990 to 2013, and extracted follow-up data to their fifth birthday. We calculate incidence rates (IR) of GI and respiratory tract infections, overall and stratified by age, sex, socioeconomic status and gestational age at birth, and compared these between children with and without gastroschisis by calculating adjusted incidence rate ratios (aIRR).
Results: Children with gastroschisis had a 65% higher IR of GI infection compared to children without (aIRR 1.65, 95% CI 1.37-1.99, p

Citation

Bannister, J., Szatkowski, L., Sharkey, D., Tan, S., Fiaschi, L., & Ban, L. (2018). Early life incidence of gastrointestinal and respiratory infections in children with gastroschisis: a cohort study. Journal of Pediatric Gastroenterology and Nutrition, 67(5), 580–585. doi:10.1097/MPG.0000000000002045

Journal Article Type Article
Acceptance Date May 11, 2018
Online Publication Date May 30, 2018
Publication Date 2018-11
Deposit Date May 15, 2018
Publicly Available Date May 31, 2019
Journal Journal of Pediatric Gastroenterology and Nutrition
Print ISSN 0277-2116
Electronic ISSN 1536-4801
Publisher Lippincott, Williams & Wilkins
Peer Reviewed Peer Reviewed
Volume 67
Issue 5
Pages 580–585
DOI https://doi.org/10.1097/MPG.0000000000002045
Public URL http://eprints.nottingham.ac.uk/id/eprint/51776
Publisher URL https://journals.lww.com/jpgn/Abstract/publishahead/Early_Life_Incidence_of_Gastrointestinal_and.96797.aspx
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf
Additional Information This is not the final published version. The final published version Bannister, Jessica, Szatkowski, Lisa, Sharkey, Don, Tan, Shin, Fiaschi, Linda, Ban, Lu. Early life incidence of gastrointestinal and respiratory infections in children with gastroschisis: a cohort study. Journal of Pediatric Gastroenterology and Nutrition
is available at https://journals.lww.com/jpgn/Abstract/publishahead/Early_Life_Incidence_of_Gastrointestinal_and.96797.aspx

Files


Infections in children with gastroschisis - eprints.pdf (340 Kb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





You might also like



Downloadable Citations