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Monosodium urate crystal deposits are common in asymptomatic sons of people with gout: The Sons of gout study

Abhishek, Abhishek; Courtney, Philip; Jenkins, Wendy; Sandoval-Plata, Gabriela; Jones, Adrian; Zhang, Weiya; Doherty, Michael

Monosodium urate crystal deposits are common in asymptomatic sons of people with gout: The Sons of gout study Thumbnail


Authors

Philip Courtney

Wendy Jenkins

Gabriela Sandoval-Plata

Adrian Jones

Michael Doherty



Abstract

Objective To estimate the prevalence and distribution of asymptomatic monosodium urate (MSU) crystal deposition in sons of people with gout.

Method People with gout were mailed an explanatory letter enclosing a postage-paid study-pack to mail to their son(s) ≥20 years old. Sons interested in participating returned a reply-slip and underwent telephone screening. Subsequently they attended a study-visit for blood and urine collection, and musculoskeletal ultrasonography performed blind to serum urate (SU). Images were assessed for double contour sign (DCS), intra-articular or intra-tendinous aggregates/tophi, effusion and power Doppler. Logistic regression was used to examine associations.

Results 131 sons (mean age 43.80 years, body mass index 27.10 kg/m2) completed assessments. 64.1% had SU ≥6 mg/dl, and 29.8% had either DCS or intra-articular aggregates/tophi in ≥1 joint. All participants with MSU deposition had involvement of either 1st metatarsophalangeal joint. 21.4% had intra-tendinous aggregates, and these associated with intra-articular MSU crystal deposits (aOR (95%CI) 2.96(1.17-7.49)). No participant had MSU crystal deposition at SU ≤5 mg/dl, and 24.2% participants with SU between 5-6 mg/dl had ultrasonographic MSU deposition. MSU crystal deposition associated with increasing SU (aOR (95%CI) 1.61(1.10-2.36) for each 1 mg/dl increase).

Conclusion Asymptomatic sons of people with gout frequently have hyperuricemia and MSU crystal deposits. In this study MSU crystal deposits were present in participants with SU >5 mg/dl. Evaluation of people without a family history of gout is needed to confirm if the threshold for MSU crystal deposition is also lower in the general population.

Citation

Abhishek, A., Courtney, P., Jenkins, W., Sandoval-Plata, G., Jones, A., Zhang, W., & Doherty, M. (2018). Monosodium urate crystal deposits are common in asymptomatic sons of people with gout: The Sons of gout study. Arthritis and Rheumatology, 70(11), 1847-1852. https://doi.org/10.1002/art.40572

Journal Article Type Article
Acceptance Date May 22, 2018
Online Publication Date May 27, 2018
Publication Date Nov 1, 2018
Deposit Date Jun 1, 2018
Publicly Available Date Oct 30, 2018
Journal Arthritis & Rheumatology
Print ISSN 2326-5191
Electronic ISSN 2326-5205
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 70
Issue 11
Pages 1847-1852
DOI https://doi.org/10.1002/art.40572
Keywords Gout; Crystal arthritis; Ultrasonography; Hyperuricemia; Asymptomatic gout
Public URL https://nottingham-repository.worktribe.com/output/934314
Publisher URL https://onlinelibrary.wiley.com/doi/abs/10.1002/art.40572
Contract Date Jun 1, 2018

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