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Enantioselective nickel-catalyzed arylative intramolecular 1,4allylations

Nguyen, Thi Le Nhon; Incerti-Pradillos, Celia A.; Lewis, William; Lam, Hon Wai

Authors

Thi Le Nhon Nguyen

Celia A. Incerti-Pradillos

William Lewis

HON LAM Hon.Lam@nottingham.ac.uk
Professor of Sustainable Chemistry



Abstract

The enantioselective nickel-catalyzed desymmetrization of allenyl cyclohexa-2,5-dienones by reaction with arylboronic acids is described. Nickel-catalyzed arylation of the allene gives allylnickel species, which undergo cyclization by 1,4allylation to produce hexahydroindol-5-ones and hexahydrofuran-5-ones with three contiguous stereocenters in high diastereo- and enantioselectivities.

Citation

Nguyen, T. L. N., Incerti-Pradillos, C. A., Lewis, W., & Lam, H. W. (in press). Enantioselective nickel-catalyzed arylative intramolecular 1,4allylations. Chemical Communications, https://doi.org/10.1039/C8CC03204A

Journal Article Type Article
Acceptance Date May 9, 2018
Online Publication Date May 9, 2018
Deposit Date May 11, 2018
Publicly Available Date May 10, 2019
Journal Chemical Communications
Print ISSN 1359-7345
Electronic ISSN 1364-548X
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1039/C8CC03204A
Public URL http://eprints.nottingham.ac.uk/id/eprint/51692
Publisher URL http://pubs.rsc.org/en/Content/ArticleLanding/2018/CC/C8CC03204A#!divAbstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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