Else Charlotte Sandset
Protocol for a prospective collaborative systematic review and meta-analysis of individual patient data from randomised controlled trials of vasoactive drugs in acute stroke: the Blood pressure in Acute Stroke Collaboration, stage-3
Sandset, Else Charlotte; Sanossian, Nerses; Woodhouse, Lisa J.; Anderson, Craig; Berge, Eivind; Lees, Kennedy R.; Potter, John F.; Robinson, Thompson G.; Sprigg, Nikola; Wardlow, Joanna M.; Bath, Philip M.W.
Authors
Nerses Sanossian
Dr LISA WOODHOUSE L.Woodhouse@nottingham.ac.uk
Research Fellow
Craig Anderson
Eivind Berge
Kennedy R. Lees
John F. Potter
Thompson G. Robinson
NIKOLA SPRIGG nikola.sprigg@nottingham.ac.uk
Professor of Stroke Medicine
Joanna M. Wardlow
Philip M.W. Bath
Abstract
Rationale
Despite several large clinical trials assessing blood pressure lowering in acute stroke, equipoise remains, particularly for ischaemic stroke. The ‘Blood pressure in Acute Stroke Collaboration’ (BASC) commenced in the mid 1990s focusing on systematic reviews and meta-analysis of blood pressure lowering in acute stroke. From the start, BASC planned to assess safety and efficacy of blood pressure lowering in acute stroke using individual patient data.
Aims
To determine the optimal management of blood pressure in patients with acute stroke, encompassing both intracerebral haemorrhage and ischaemic stroke. Secondary aims are to assess which clinical and therapeutic factors may alter the optimal management of high blood pressure in patients with acute stroke and to assess the effect of vasoactive treatments on haemodynamic variables.
Methods and design
Individual patient data from randomised controlled trials of blood pressure management in participants with ischaemic stroke and/or intracerebral haemorrhage enrolled during the ultra-acute (pre-hospital), hyper-acute (
| Journal Article Type | Article |
|---|---|
| Acceptance Date | Feb 12, 2018 |
| Online Publication Date | May 3, 2018 |
| Publication Date | May 3, 2018 |
| Deposit Date | Apr 26, 2018 |
| Publicly Available Date | May 3, 2018 |
| Journal | International Journal of Stroke |
| Print ISSN | 1747-4930 |
| Electronic ISSN | 1747-4949 |
| Publisher | SAGE Publications |
| Peer Reviewed | Peer Reviewed |
| Volume | 13 |
| Issue | 7 |
| Pages | 759-765 |
| DOI | https://doi.org/10.1177/1747493018772733 |
| Public URL | https://nottingham-repository.worktribe.com/output/931058 |
| Publisher URL | http://journals.sagepub.com/doi/10.1177/1747493018772733 |
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