CHRISTOPHER MADAN CHRISTOPHER.MADAN@NOTTINGHAM.AC.UK
Assistant Professor
Predicting age from cortical structure across the lifespan
Madan, Christopher R.; Kensinger, Elizabeth A.
Authors
Elizabeth A. Kensinger
Abstract
Despite inter-individual differences in cortical structure, cross-sectional and longitudinal studies have demonstrated a large degree of population-level consistency in age-related differences in brain morphology. The present study assessed how accurately an individual’s age could be predicted by estimates of cortical morphology, comparing a variety of structural measures, including thickness, gyrification, and fractal dimensionality. Structural measures were calculated across up to seven different parcellation approaches, ranging from 1 region to 1000 regions. The age-prediction framework was trained using morphological measures obtained from T1-weighted MRI volumes collected from multiple sites, yielding a training dataset of 1056 healthy adults, aged 18-97. Age predictions were calculated using a machine-learning approach that incorporated non-linear differences over the lifespan. In two independent, held-out test samples, age predictions had a median error of 6-7 years. Age predictions were best when using a combination of cortical metrics, both thickness and fractal dimensionality. Overall, the results reveal that age-related differences in brain structure are systematic enough to enable reliable age prediction based on metrics of cortical morphology.
Citation
Madan, C. R., & Kensinger, E. A. (2018). Predicting age from cortical structure across the lifespan. European Journal of Neuroscience, 47(5), 399-416. https://doi.org/10.1111/ejn.13835
Journal Article Type | Article |
---|---|
Acceptance Date | Jan 15, 2018 |
Online Publication Date | Feb 12, 2018 |
Publication Date | Mar 3, 2018 |
Deposit Date | Jan 16, 2018 |
Publicly Available Date | Feb 13, 2019 |
Journal | European Journal of Neuroscience |
Print ISSN | 0953-816X |
Electronic ISSN | 1460-9568 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 47 |
Issue | 5 |
Pages | 399-416 |
DOI | https://doi.org/10.1111/ejn.13835 |
Public URL | https://nottingham-repository.worktribe.com/output/918700 |
Publisher URL | http://onlinelibrary.wiley.com/doi/10.1111/ejn.13835/abstract? |
Additional Information | This is the peer reviewed version of the following article: Madan, C. R. and Kensinger, E. A. (2018), Predicting age from cortical structure across the lifespan. Eur J Neurosci, 47: 399–416, which has been published in final form at doi:10.1111/ejn.13835. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
Contract Date | Jan 16, 2018 |
Files
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