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Limited impact of adolescent meningococcal ACWY vaccination on Neisseria meningitides serogroup W carriage in university students

Oldfield, Neil J.; Green, Luke R.; Parkhill, Julian; Bayliss, Christopher D.; Turner, David P.J.

Authors

Luke R. Green

Julian Parkhill

Christopher D. Bayliss

DAVID TURNER david.turner@nottingham.ac.uk
Clinical Associate Professor



Abstract

Background

In the UK rising disease levels due to Neisseria meningitidis serogroup W clonal complex ST-11 (MenW:cc11) strains led to introduction of conjugate MenACWY vaccination for teenagers. We investigated the impact of immunization on carriage of targeted meningococci by whole genome sequencing of isolates recovered from a cohort of vaccinated university students.

Methods

Strain designation data were extracted from whole genome sequence data. Genomes from carried and invasive MenW:cc11 were compared using a gene-by-gene approach. Serogrouping identified isolates expressing capsule antigens targeted by the vaccine.

Results

Isolates with a W: P1.5,2: F1-1: ST-11 (cc11) designation, and belonging to the emerging ‘2013-strain’ of the South American-UK MenW:cc11 sub-lineage, were responsible for an increase in carried group W. A multifocal expansion was evident with close transmission networks extending beyond individual dormitories. Carried group Y isolates were predominantly from clonal complex 23, but showed significant heterogeneity and individual strain designations were only sporadically recovered. No shifts towards acapsulate phenotypes were detected in targeted meningococcal populations.

Conclusions

In a setting with high levels of conjugate MenACWY vaccination, expansion of capsule-expressing isolates from the 2013-strain of MenW:cc11, but not MenY:cc23 isolates, is indicative of differential susceptibilities to vaccine-induced immunity.

Journal Article Type Article
Publication Date Jan 30, 2018
Journal Journal of Infectious Diseases
Print ISSN 0022-1899
Electronic ISSN 1537-6613
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 217
Issue 4
APA6 Citation Oldfield, N. J., Green, L. R., Parkhill, J., Bayliss, C. D., & Turner, D. P. (2018). Limited impact of adolescent meningococcal ACWY vaccination on Neisseria meningitides serogroup W carriage in university students. Journal of Infectious Diseases, 217(4), https://doi.org/10.1093/infdis/jix596
DOI https://doi.org/10.1093/infdis/jix596
Keywords Neisseria meningitidis; Whole genome sequencing; Carriage; Serogroup W; Serogroup Y; Epidemiology; Vaccine
Publisher URL https://academic.oup.com/jid/article/4633891
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information This is a pre-copyedited, author-produced version of an article accepted for publication in Journal of Infectious Diseases following peer review. The version of record Neil J Oldfield, Luke R Green, Julian Parkhill, Christopher D Bayliss, David P J Turner; Limited Impact of Adolescent Meningococcal ACWY Vaccination on Neisseria meningitidis Serogroup W Carriage in University Students, The Journal of Infectious Diseases, Volume 217, Issue 4, 30 January 2018, Pages 608–616 is available online at: https://doi.org/10.1093/infdis/jix596

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Oldfield et al_J Infect Dis_MenWY carriage_ePrints.pdf (5.3 Mb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf


jix596 (002).pdf (7.1 Mb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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