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Stillbirth among women prescribed nicotine replacement therapy in pregnancy: analysis of a large UK pregnancy cohort

Dhalwani, Nafeesa N.; Szatkowski, Lisa; Coleman, Tim; Fiaschi, Linda; Tata, Laila J.

Authors

Nafeesa N. Dhalwani nnd2@le.ac.uk

Lisa Szatkowski lisa.szatkowski@nottingham.ac.uk

Tim Coleman tim.coleman@nottingham.ac.uk

Linda Fiaschi linda.fiaschi@nottingham.ac.uk

Laila J. Tata laila.tata@nottingham.ac.uk



Abstract

Objective: To compare risk of stillbirth between maternal smokers and those prescribed NRT during pregnancy.

Design: Cross-sectional analysis nested in a pregnancy cohort with longitudinal routinely-recorded medical data.

Setting: United Kingdom primary care; The Health Improvement Network (THIN) general practice database

Population: 220,630 singleton pregnancies ending in live or stillbirth, 2001-2012

Methods: Women were categorised into three groups: NRT (prescribed during pregnancy or one month before conception); smokers; controls (non-smokers without a pregnancy NRT prescription).

Main Outcome Measure: odds ratios (OR) adjusted to maternal characteristics and 95% confidence intervals (CIs) for stillbirth

Results: A total of 805 pregnancies ended in stillbirth (3.6/1,000 births). Absolute risks of stillbirth in NRT and smoker groups were both 5/1,000 births compared with 3.5/1,000 births in the control group. Compared with the control group, the adjusted odds of stillbirth in the NRT group was not statistically significant (OR=1.35, 95% CI 0.91-2.00), although it was similar in magnitude to that in the smokers group (OR=1.41, 95% CI 1.13-1.77).


Conclusions: We found no evidence of a statistically significant association between being prescribed NRT during pregnancy and odds of stillbirth compared with non-smoking women. Although our study had much larger numbers than any previously, an even larger study with biochemically-validated smoking outcome data and close monitoring of NRT use throughout pregnancy is required to exclude effects on findings of potential exposure misclassification.

Journal Article Type Article
Publication Date Apr 1, 2019
Journal Nicotine and Tobacco Research
Print ISSN 1462-2203
Electronic ISSN 1469-994X
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 21
Issue 4
Pages 409–415
APA6 Citation Dhalwani, N. N., Szatkowski, L., Coleman, T., Fiaschi, L., & Tata, L. J. (2019). Stillbirth among women prescribed nicotine replacement therapy in pregnancy: analysis of a large UK pregnancy cohort. Nicotine and Tobacco Research, 21(4), 409–415. https://doi.org/10.1093/ntr/nty019
DOI https://doi.org/10.1093/ntr/nty019
Keywords Stillbirth; Nicotine replacement therapy; Smoking; Pregnancy; Maternal smoking
Publisher URL https://academic.oup.com/ntr/article/21/4/409/4831224
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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