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Synthetic light-curable polymeric materials provide a supportive niche for dental pulp stem cells

Vining, Kyle H.; Scherba, Jacob C.; Bever, Alaina; Alexander, Morgan R.; Celiz, Adam D.; Mooney, David J.

Authors

Kyle H. Vining

Jacob C. Scherba

Alaina Bever

Adam D. Celiz

David J. Mooney



Abstract

Dental disease annually affects billions of patients, and while regenerative dentistry aims to heal dental tissue after injury, existing polymeric restorative materials, or fillings, do not directly participate in the healing process in a bioinstructive manner. There is a need for restorative materials that can support native functions of dental pulp stem cells (DPSCs), which are capable of regenerating dentin. A polymer microarray formed from commercially available monomers to rapidly identify materials that support DPSC adhesion is used. Based on these findings, thiol-ene chemistry is employed to achieve rapid light-curing and minimize residual monomer of the lead materials. Several triacrylate bulk polymers support DPSC adhesion, proliferation, and differentiation in vitro, and exhibit stiffness and tensile strength similar to existing dental materials. Conversely, materials composed of a trimethacrylate monomer or bisphenol A glycidyl methacrylate, which is a monomer standard in dental materials, do not support stem cell adhesion and negatively impact matrix and signaling pathways. Furthermore, thiol-ene polymerized triacrylates are used as permanent filling materials at the dentin-pulp interface in direct contact with irreversibly injured pulp tissue. These novel triacrylate-based biomaterials have potential to enable novel regenerative dental therapies in the clinic by both restoring teeth and providing a supportive niche for DPSCs.

Journal Article Type Article
Publication Date Jan 25, 2018
Journal Advanced Materials
Print ISSN 0935-9648
Electronic ISSN 1521-4095
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 30
Issue 4
Article Number 1704486
APA6 Citation Vining, K. H., Scherba, J. C., Bever, A., Alexander, M. R., Celiz, A. D., & Mooney, D. J. (2018). Synthetic light-curable polymeric materials provide a supportive niche for dental pulp stem cells. Advanced Materials, 30(4), https://doi.org/10.1002/adma.201704486
DOI https://doi.org/10.1002/adma.201704486
Keywords dental materials; dental pulp stem cells; multi-functional acrylates, polymer microarray; differentiation
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/adma.201704486/abstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information This is the peer reviewed version of the following article: K. H. Vining, J. C. Scherba, A. M. Bever, M. R. Alexander, A. D. Celiz, D. J. Mooney, Adv. Mater. 2017, 1704486, which has been published in final form at http://dx.doi.org/10.1002/adma.201704486. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

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adma.201704486_accepted manuscript - corrected.pdf (2.3 Mb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf


Adv Mater Vining_supplementary_final edits.pdf (7.4 Mb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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