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Duration and magnitude of postoperative risk of venous thromboembolism after planned inguinal hernia repair in men: a population-based cohort study

Humes, D.J.; Abdul-Sultan, Alyshah; Walker, Alex J.; Ludvigsson, Jonas F.; West, Joe

Authors

DAVID HUMES david.humes@nottingham.ac.uk
Clinical Associate Professor

Alyshah Abdul-Sultan

Alex J. Walker alex.walker@nottingham.ac.uk

Jonas F. Ludvigsson

JOE WEST JOE.WEST@NOTTINGHAM.AC.UK
Professor of Epidemiology



Abstract

Purpose
Little is known regarding the magnitude and timing of the risk of VTE following inguinal hernia surgery. We aimed to determine the absolute and relative rates of venous thromboembolism (VTE) following planned inguinal hernia repair.
Methods
We analysed male adults with a first inguinal hernia repair with no prior record of VTE from the Clinical Practice Research Datalink, linked to the Hospital Episode Statistics (2001–2011). Crude rates and adjusted hazard ratios (HR) of the first VTE were calculated using Cox regression analysis to compare specific time periods following the surgery compared to the general population.
Results
We identified 28,782 men who underwent an inguinal hernia repair with 53 (0.18%) having a first VTE in the 90 days following surgery. The overall rate of VTE in the first 90 days following surgery was 7.61 per 1000 person years (pyrs) (95% CI 5.82–9.96). Increasing age, a body mass index > 30 kg/m2 and an in-patient procedure were associated with an increased risk of VTE, when compared to the general population. The risk of VTE was highest in the 1st month following the surgery with a 2.3- (aHR 2.33; 95% CI 1.09–4.99) and 3.5- (aHR 3.47; 95% CI 2.07–5.83) fold increased risk compared to the general population for both day case and planned in-patient procedures, respectively.
Conclusions
Reassuringly, the absolute rates of VTE following inguinal hernia repair are low. Patients should be informed that their peak risk of VTE is during the 1st month following the surgery. Further studies on the optimum duration of thromboprophylaxis following surgery are required in high-risk patients undergoing hernia repair.

Citation

Humes, D., Abdul-Sultan, A., Walker, A. J., Ludvigsson, J. F., & West, J. (in press). Duration and magnitude of postoperative risk of venous thromboembolism after planned inguinal hernia repair in men: a population-based cohort study. Hernia, https://doi.org/10.1007/s10029-017-1716-6

Journal Article Type Article
Acceptance Date Dec 13, 2017
Online Publication Date Jan 15, 2018
Deposit Date Jan 31, 2018
Publicly Available Date Jan 16, 2019
Journal Hernia
Print ISSN 1265-4906
Electronic ISSN 1248-9204
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1007/s10029-017-1716-6
Keywords Venous thrombosis, inguinal hernia, surgery
Public URL http://eprints.nottingham.ac.uk/id/eprint/49393
Publisher URL https://link.springer.com/article/10.1007%2Fs10029-017-1716-6
Related Public URLs https://doi.org/10.1007/s10029-017-1716-6
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf
Additional Information This is a post-peer-review, pre-copyedit version of an article published in Hernia. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10029-017-1716-6.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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