Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging
Zamberlan, F.; Turyanska, L.; Patanè, A.; Liu, Z.; Williams, H.E.L.; Fay, M.W.; Clarke, P.A.; Imamura, Y.; Jin, T.; Bradshaw, T.D.; Thomas, N.R.; Grabowska, A.M.
Dr MICHAEL FAY MICHAEL.FAY@NOTTINGHAM.AC.UK
Senior Research Fellow
The short shelf-life of water-soluble quantum dots (QDs) due to colloidal instability represents a major drawback to their exploitation. This work examines the colloidal stability of PbS nanoparticles capped with dihydrolipoic acid–polyethylene glycol (DHLA–PEG) ligands terminated with functional groups such as –NH 2 , –COOH, OMe and –N3 and their application for in vivo imaging. We prove a mechanism of colloidal instability and develop a strategy to produce for the first time stable PEG-capped PbS quantum dots with high quantum yield and optical emission in the first and the second near-infrared (NIR) windows of low absorption of biological tissues. The NIR imaging of in vivo biodistribution is demonstrated at wavelengths 4 1000 nm, with benefits of reduced tissue absorption and light scattering. The stability, biocompatibility and potential for further QD functionalization open up realistic prospects for non-invasive bioimaging applications.
|Journal Article Type||Article|
|Journal||Journal of Materials Chemistry B|
|Publisher||Royal Society of Chemistry|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Zamberlan, F., Turyanska, L., Patanè, A., Liu, Z., Williams, H., Fay, M., …Grabowska, A. (in press). Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging. Journal of Materials Chemistry B, 6, https://doi.org/10.1039/c7tb02912h|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0|
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0