F. Zamberlan
Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging
Authors
Dr LYUDMILA TURYANSKA lyudmila.turyanska@nottingham.ac.uk
Associate Professor
Professor AMALIA PATANE amalia.patane@nottingham.ac.uk
Professor of Physics
Z. Liu
HUW WILLIAMS HUW.WILLIAMS@NOTTINGHAM.AC.UK
Senior Research Fellow
Dr MICHAEL FAY MICHAEL.FAY@NOTTINGHAM.AC.UK
Senior Research Fellow
P.A. Clarke
Y. Imamura
T. Jin
Dr TRACEY BRADSHAW tracey.bradshaw@nottingham.ac.uk
Associate Professor
NEIL THOMAS neil.thomas@nottingham.ac.uk
Professor of Medicinal and Biological Chemistry
ANNA GRABOWSKA anna.grabowska@nottingham.ac.uk
Professor of Cancer Microenvironment
Abstract
The short shelf-life of water-soluble quantum dots (QDs) due to colloidal instability represents a major drawback to their exploitation. This work examines the colloidal stability of PbS nanoparticles capped with dihydrolipoic acid–polyethylene glycol (DHLA–PEG) ligands terminated with functional groups such as –NH 2 , –COOH, OMe and –N3 and their application for in vivo imaging. We prove a mechanism of colloidal instability and develop a strategy to produce for the first time stable PEG-capped PbS quantum dots with high quantum yield and optical emission in the first and the second near-infrared (NIR) windows of low absorption of biological tissues. The NIR imaging of in vivo biodistribution is demonstrated at wavelengths 4 1000 nm, with benefits of reduced tissue absorption and light scattering. The stability, biocompatibility and potential for further QD functionalization open up realistic prospects for non-invasive bioimaging applications.
Citation
Zamberlan, F., Turyanska, L., Patanè, A., Liu, Z., Williams, H., Fay, M., …Grabowska, A. (in press). Stable DHLA–PEG capped PbS quantum dots: from synthesis to near-infrared biomedical imaging. Journal of Materials Chemistry B, 6, https://doi.org/10.1039/c7tb02912h
Journal Article Type | Article |
---|---|
Acceptance Date | Dec 15, 2017 |
Online Publication Date | Jan 12, 2018 |
Deposit Date | Jan 8, 2018 |
Publicly Available Date | Jan 12, 2018 |
Journal | Journal of Materials Chemistry B |
Print ISSN | 2050-750X |
Electronic ISSN | 2050-7518 |
Publisher | Royal Society of Chemistry |
Peer Reviewed | Peer Reviewed |
Volume | 6 |
DOI | https://doi.org/10.1039/c7tb02912h |
Public URL | https://nottingham-repository.worktribe.com/output/904517 |
Publisher URL | http://pubs.rsc.org/en/content/articlehtml/2018/tb/c7tb02912h |
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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