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Insulin-Like Peptide 3 (INSL3)

Anand-Ivell, Ravinder; Ivell, Richard


Richard Ivell


Ilpo Huhtaniemi

Luciano Martini


© 2019 Elsevier Inc. Insulin-like peptide 3 (INSL3) is a major secretory product of the steroidogenic Leydig cells of the testes in the fetus as well as in the adult. It is a constitutive product of the mature Leydig cells and hence acts as an excellent biomarker for Leydig cell functional capacity, and can be used to monitor fetal and pubertal development, as well as male aging. Its major function is to promote the first transabdominal phase of testis descent in the fetus, interacting with RXFP2 receptors on the gubernacular ligaments. It also has functions in the adult linked to spermatogenesis, steroidogenesis, and bone metabolism. INSL3 is also produced in the female as a paracrine system within the ovary serving to promote steroidogenesis within growing antral follicles.


Anand-Ivell, R., & Ivell, R. (2018). Insulin-Like Peptide 3 (INSL3). In I. Huhtaniemi, & L. Martini (Eds.), Encyclopedia of Endocrine Diseases (793-806). (Second). Elsevier.

Acceptance Date Jan 13, 2018
Online Publication Date Oct 5, 2018
Publication Date Oct 5, 2018
Deposit Date Jan 26, 2018
Peer Reviewed Peer Reviewed
Pages 793-806
Edition Second
Book Title Encyclopedia of Endocrine Diseases
ISBN 9780128121993
Keywords Insulin-like peptide 3, relaxin, RXFP2, cryptorchidism, testis descent, puberty, male ageing, Leydig cells, testosterone, ovarian antral follicles, PCOS
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