Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data
Sarmanova, Aliya; Hall, Michelle C.; Fernandes, Gwen Sascha; Bhattacharya, Archan; Valdes, Ana M.; Walsh, David A.; Doherty, Michael; Zhang, Weiya
Michelle C. Hall
Gwen Sascha Fernandes
Professor ANA VALDES Ana.Valdes@nottingham.ac.uk
Professor of Molecular & Genetic Epidemiology
DAVID WALSH firstname.lastname@example.org
Professor of Rheumatology
Professor WEIYA ZHANG WEIYA.ZHANG@NOTTINGHAM.AC.UK
Professor of Epidemiology
Background: Recently an important role for synovial pathology in the initiation and progression of knee osteoarthritis (OA) has been emphasised. This study aimed to examine whether ultrasonographydetected synovial changes (USSCs) associate with knee pain (KP) in a community population.
Methods: A case-control study was conducted to compare people with early KP (n=298), established KP (n=100) or no KP (n=94) at baseline. Multinomial logistic regression was used to estimate odds ratio (OR) and 95% confidence interval (CI) between groups adjusted for radiographic osteoarthritis (ROA) severity and other confounding factors. After one year 255 participants with early and established KP completed the followup questionnaire for changes in KP. Logistic regression with adjustment was used to determine predictors of KP worsening.
Results: At baseline, effusion was associated with early (OR 2.64, 95%CI 1.57 to 4.45) and established KP (OR 5.07, 95%CI 2.74 to 9.38). Synovial hypertrophy was also associated with early (OR 5.43, 95%CI 2.12 to 13.92) and established KP (OR 13.27, 95%CI 4.97 to 35.43). The association with effusion diminished when adjusted for ROA. Power Doppler signal was uncommon (early KP 3%, established KP 2%, controls 0%). Baseline effusion predicted worsening of knee pain at one year (OR 1.95, 95% CI 1.05 to 3.64). However, after adjusting for ROA, the prediction was insignificant (aORs 0.95, 95%CI 0.44 to 2.02).
Conclusion: US effusion and synovial hypertrophy are associated with KP, but only effusion predicts KP worsening. However, the association/prediction are not independent from ROA. Power Doppler signal is uncommon in people with KP. Further study is needed to understand whether synovitis is directly involved in different types of KP.
Sarmanova, A., Hall, M. C., Fernandes, G. S., Bhattacharya, A., Valdes, A. M., Walsh, D. A., …Zhang, W. (in press). Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data. Arthritis Research and Therapy, 19(281), https://doi.org/10.1186/s13075-017-1486-7
|Journal Article Type||Article|
|Acceptance Date||Nov 24, 2017|
|Online Publication Date||Dec 19, 2017|
|Deposit Date||Dec 12, 2017|
|Publicly Available Date||Dec 19, 2017|
|Journal||Arthritis Research & Therapy|
|Peer Reviewed||Peer Reviewed|
|Keywords||knee pain, synovial changes, synovitis, ultrasound, osteoarthritis, cohort study|
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
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