DANIEL WILKINSON DANIEL.WILKINSON@NOTTINGHAM.AC.UK
Principal Research Fellow
Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism
Wilkinson, Daniel J.; Hossain, T.; Limb, Marie C.; Phillips, Bethan E.; Lund, J.; Williams, John P.; Brook, Matthew S.; Cegielski, Jessica; Philp, A.; Ashcroft, S.; Rathmacher, J. A.; Szewczyk, N. J.; Smith, K.; Atherton, Philip J.
Authors
T. Hossain
Marie C. Limb
BETH PHILLIPS beth.phillips@nottingham.ac.uk
Professor of Translational Physiology
JONATHAN LUND JON.LUND@NOTTINGHAM.AC.UK
Clinical Associate Professor
JOHN WILLIAMS john.williams7@nottingham.ac.uk
Clinical Associate Professor
MATTHEW BROOK MATTHEW.BROOK@NOTTINGHAM.AC.UK
Assistant Professor
Jessica Cegielski
A. Philp
S. Ashcroft
J. A. Rathmacher
N. J. Szewczyk
KENNETH SMITH KEN.SMITH@NOTTINGHAM.AC.UK
Professor of Metabolic Mass Spectrometry
PHILIP ATHERTON philip.atherton@nottingham.ac.uk
Professor of Clinical, metabolic & Molecular Physiology
Abstract
© 2017 The Authors Background & aims: β-hydroxy-β-methylbutyrate (HMB) is purported as a key nutritional supplement for the preservation of muscle mass in health, disease and as an ergogenic aid in exercise. Of the two available forms of HMB (calcium (Ca-HMB) salt or free acid (FA-HMB)) – differences in plasma bioavailability have been reported. We previously reported that ∼3 g oral FA-HMB increased muscle protein synthesis (MPS) and reduced muscle protein breakdown (MPB). The objective of the present study was to quantify muscle protein metabolism responses to oral Ca-HMB. Methods: Eight healthy young males received a primed constant infusion of 1,2 13C2 leucine and 2H5 phenylalanine to assess MPS (by tracer incorporation in myofibrils) and MPB (via arterio-venous (A-V) dilution) at baseline and following provision of ∼3 g of Ca-HMB; muscle anabolic (MPS) and catabolic (MPB) signalling was assessed via immunoblotting. Results: Ca-HMB led a significant and rapid (
Citation
Wilkinson, D. J., Hossain, T., Limb, M. C., Phillips, B. E., Lund, J., Williams, J. P., …Atherton, P. J. (2018). Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism. Clinical Nutrition, 37(6), 2068-2075. https://doi.org/10.1016/j.clnu.2017.09.024
Journal Article Type | Article |
---|---|
Acceptance Date | Sep 29, 2017 |
Online Publication Date | Oct 6, 2017 |
Publication Date | Dec 1, 2018 |
Deposit Date | Nov 8, 2017 |
Publicly Available Date | Nov 8, 2017 |
Journal | Clinical Nutrition |
Print ISSN | 0261-5614 |
Electronic ISSN | 1532-1983 |
Publisher | Elsevier |
Peer Reviewed | Peer Reviewed |
Volume | 37 |
Issue | 6 |
Pages | 2068-2075 |
DOI | https://doi.org/10.1016/j.clnu.2017.09.024 |
Keywords | β-Hydroxy-β-methylbutyrate; Skeletal muscle; Protein metabolism; Anabolism |
Public URL | https://nottingham-repository.worktribe.com/output/886710 |
Publisher URL | https://www.sciencedirect.com/science/article/pii/S0261561417313560 |
Additional Information | This article is maintained by: Elsevier; Article Title: Impact of the calcium form of β-hydroxy-β-methylbutyrate upon human skeletal muscle protein metabolism; Journal Title: Clinical Nutrition; CrossRef DOI link to publisher maintained version: https://doi.org/10.1016/j.clnu.2017.09.024; Content Type: article; Copyright: © 2017 The Authors. Published by Elsevier Ltd. |
Contract Date | Nov 8, 2017 |
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Copyright Statement
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