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Smoking cessation and survival in lung, upper aero-digestive tract and bladder cancer: cohort study

Koshiaris, C.; Aveyard, P.; Oke, J.; Ryan, R.; Szatkowski, Lisa; Stevens, R.; Farley, A.

Authors

C. Koshiaris

P. Aveyard

J. Oke

R. Ryan

R. Stevens

A. Farley



Abstract

Background: The aim was to examine the association between smoking cessation and prognosis in smoking-related cancer as it is unclear that cessation reduces mortality.

Methods: In this retrospective cohort study from 1999 to 2013, we assessed the association between cessation during the first year after diagnosis and all-cause and cancer- specific mortality.

Results: Of 2,882 lung, 757 upper aero-digestive tract and 1,733 bladder cancer patients 27%, 29% and 21% of lung, UAT and bladder cancer patients quit smoking. In lung cancer patients that quit, all-cause mortality was significantly lower (HR 0.82 (0.74-0.92), while cancer-specific mortality (HR 0.89 (0.76-1.04) and death due to index cancer (HR 0.90 (0.77-1.05) were nonsignificantly lower. In UAT cancer, all-cause mortality (HR 0.81 (0.58-1.14), cancer-specific mortality (HR 0.84 (0.48-1.45), and death due to index cancer (HR 0.75 (0.42-1.34) were non-significantly lower. There was no evidence of an association between quitting and mortality in bladder cancer. The HRs were 1.02 (0.81 1.30) for all-cause, 1.23 (0.81-1.86) for cancer specific, and 1.25 (0.71-2.20) for death due to index cancer. These showed a nonsignificantly lower risk in sensitivity analyses.

Conclusion: People with lung and possibly UAT cancer who quit smoking have a lower risk of mortality than people who continue smoking.

Citation

Koshiaris, C., Aveyard, P., Oke, J., Ryan, R., Szatkowski, L., Stevens, R., & Farley, A. (in press). Smoking cessation and survival in lung, upper aero-digestive tract and bladder cancer: cohort study. British Journal of Cancer, 117, https://doi.org/10.1038/bjc.2017.179

Journal Article Type Article
Acceptance Date May 26, 2017
Online Publication Date Sep 12, 2017
Deposit Date Jul 19, 2017
Publicly Available Date Sep 12, 2017
Journal British Journal of Cancer
Print ISSN 0007-0920
Electronic ISSN 1532-1827
Publisher Cancer Research UK
Peer Reviewed Peer Reviewed
Volume 117
DOI https://doi.org/10.1038/bjc.2017.179
Keywords Smoking, Smoking cessation, Cancer, Primary care
Public URL http://eprints.nottingham.ac.uk/id/eprint/44245
Publisher URL http://www.nature.com/bjc/journal/vaop/ncurrent/full/bjc2017179a.html
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Smoking cessation and survival in lung upper aerodigestive tract and bladder cancer.pdf (589 Kb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0


Smoking bjc2017179a.pdf (396 Kb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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