Smoking cessation and survival in lung, upper aero-digestive tract and bladder cancer: cohort study

Koshiaris, C.; Aveyard, P.; Oke, J.; Ryan, R.; Szatkowski, Lisa; Stevens, R.; Farley, A.

Abstract

Background: The aim was to examine the association between smoking cessation and prognosis in smoking-related cancer as it is unclear that cessation reduces mortality.

Methods: In this retrospective cohort study from 1999 to 2013, we assessed the association between cessation during the first year after diagnosis and all-cause and cancer- specific mortality.

Results: Of 2,882 lung, 757 upper aero-digestive tract and 1,733 bladder cancer patients 27%, 29% and 21% of lung, UAT and bladder cancer patients quit smoking. In lung cancer patients that quit, all-cause mortality was significantly lower (HR 0.82 (0.74-0.92), while cancer-specific mortality (HR 0.89 (0.76-1.04) and death due to index cancer (HR 0.90 (0.77-1.05) were nonsignificantly lower. In UAT cancer, all-cause mortality (HR 0.81 (0.58-1.14), cancer-specific mortality (HR 0.84 (0.48-1.45), and death due to index cancer (HR 0.75 (0.42-1.34) were non-significantly lower. There was no evidence of an association between quitting and mortality in bladder cancer. The HRs were 1.02 (0.81 1.30) for all-cause, 1.23 (0.81-1.86) for cancer specific, and 1.25 (0.71-2.20) for death due to index cancer. These showed a nonsignificantly lower risk in sensitivity analyses.

Conclusion: People with lung and possibly UAT cancer who quit smoking have a lower risk of mortality than people who continue smoking.

Citation

Koshiaris, C., Aveyard, P., Oke, J., Ryan, R., Szatkowski, L., Stevens, R., & Farley, A. (in press). Smoking cessation and survival in lung, upper aero-digestive tract and bladder cancer: cohort study. British Journal of Cancer, 117, https://doi.org/10.1038/bjc.2017.179

• Journal Article Type: Article
• Acceptance Date: May 26, 2017
• Online Publication Date: Sep 12, 2017
• Deposit Date: Jul 19, 2017
• Publicly Available Date: Sep 12, 2017
• Journal: British Journal of Cancer
• Print ISSN: 0007-0920
• Electronic ISSN: 1532-1827
• Publisher: Cancer Research UK
• Peer Reviewed: Peer Reviewed
• Volume: 117
• DOI: https://doi.org/10.1038/bjc.2017.179
• Keywords: Smoking, Smoking cessation, Cancer, Primary care
• Public URL: https://nottingham-repository.worktribe.com/output/882515
• Publisher URL: http://www.nature.com/bjc/journal/vaop/ncurrent/full/bjc2017179a.html