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A new generation of magnetoencephalography: Room temperature measurements using optically-pumped magnetometers

Boto, Elena; Meyer, Sofie S.; Shah, Vishal; Alem, Orang; Knappe, Svenja; Kruger, Peter; Fromhold, T. Mark; Lim, Mark; Glover, Paul M.; Morris, Peter G.; Bowtell, Richard; Barnes, Gareth R.; Brookes, Matthew J.

Authors

Sofie S. Meyer

Vishal Shah

Orang Alem

Svenja Knappe

Peter Kruger

Mark Lim

Gareth R. Barnes



Abstract

© 2017 The Authors Advances in the field of quantum sensing mean that magnetic field sensors, operating at room temperature, are now able to achieve sensitivity similar to that of cryogenically cooled devices (SQUIDs). This means that room temperature magnetoencephalography (MEG), with a greatly increased flexibility of sensor placement can now be considered. Further, these new sensors can be placed directly on the scalp surface giving, theoretically, a large increase in the magnitude of the measured signal. Here, we present recordings made using a single optically-pumped magnetometer (OPM) in combination with a 3D-printed head-cast designed to accurately locate and orient the sensor relative to brain anatomy. Since our OPM is configured as a magnetometer it is highly sensitive to environmental interference. However, we show that this problem can be ameliorated via the use of simultaneous reference sensor recordings. Using median nerve stimulation, we show that the OPM can detect both evoked (phase-locked) and induced (non-phase-locked oscillatory) changes when placed over sensory cortex, with signals ~4 times larger than equivalent SQUID measurements. Using source modelling, we show that our system allows localisation of the evoked response to somatosensory cortex. Further, source-space modelling shows that, with 13 sequential OPM measurements, source-space signal-to-noise ratio (SNR) is comparable to that from a 271-channel SQUID system. Our results highlight the opportunity presented by OPMs to generate uncooled, potentially low-cost, high SNR MEG systems.

Citation

Boto, E., Meyer, S. S., Shah, V., Alem, O., Knappe, S., Kruger, P., …Brookes, M. J. (2017). A new generation of magnetoencephalography: Room temperature measurements using optically-pumped magnetometers. NeuroImage, 149, 404-414. https://doi.org/10.1016/j.neuroimage.2017.01.034

Journal Article Type Article
Acceptance Date Jan 15, 2017
Online Publication Date Jan 25, 2017
Publication Date Apr 1, 2017
Deposit Date Feb 13, 2017
Publicly Available Date Feb 13, 2017
Journal NeuroImage
Print ISSN 1053-8119
Electronic ISSN 1095-9572
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 149
Pages 404-414
DOI https://doi.org/10.1016/j.neuroimage.2017.01.034
Public URL http://eprints.nottingham.ac.uk/id/eprint/40566
Publisher URL http://www.sciencedirect.com/science/article/pii/S1053811917300411
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0







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