Similarity- and substructure-based development of ?2-adrenergic receptor ligands based on unusual scaffolds

Schmidt, Denis; Gunera, Jakub; Baker, Jillian G.; Kolb, Peter

Abstract

The ?2-adrenergic receptor (?2AR) is a G protein-coupled receptor (GPCR) and a well-explored target. Here, we report the discovery of 13 ligands, ten of which are novel, of this particular GPCR. They have been identified by similarity- and substructure-based searches using multiple ligands, which were described in an earlier study, as starting points. Of note, two of the molecules used as queries here distinguish themselves from other ?2AR antagonists by their unique scaffold. The molecules described in this work allow us to explore the ligand space around the previously reported molecules in greater detail, leading to insights into their structure?activity relationship. We also report experimental binding and selectivity data and putative binding modes for the novel molecules.

Citation

Schmidt, D., Gunera, J., Baker, J. G., & Kolb, P. (in press). Similarity- and substructure-based development of ?2-adrenergic receptor ligands based on unusual scaffolds. ACS Medicinal Chemistry Letters, https://doi.org/10.1021/acsmedchemlett.6b00363

• Journal Article Type: Article
• Acceptance Date: Mar 27, 2017
• Online Publication Date: Mar 27, 2017
• Deposit Date: Apr 24, 2017
• Publicly Available Date: Apr 24, 2017
• Journal: ACS Medicinal Chemistry Letters
• Print ISSN: 1948-5875
• Electronic ISSN: 1948-5875
• Publisher: American Chemical Society
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1021/acsmedchemlett.6b00363
• Keywords: Docking; SAR-by-catalog; Similarity searches; ?2-adrenergic receptor
• Public URL: https://nottingham-repository.worktribe.com/output/852541
• Publisher URL: http://pubs.acs.org/doi/abs/10.1021/acsmedchemlett.6b00363