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Multiboronic acid-conjugated chitosan scaffolds with glucose selectivity to insulin release

Siddiqui, Nabil A.; Billa, Nashiru; Roberts, Clive J.

Authors

Nabil A. Siddiqui

Nashiru Billa

Clive J. Roberts



Abstract

The principal challenge for the use of boronic acids (BA) as glucose sensors is their lack of specificity for glucose. We examined the selectivity of and insulin release from two boronic acids- (2-formyl-3-thienylboronic acid (FTBA) and 4-formylphenylboronic acid (FPBA)) conjugated chitosan scaffolds to glucose and fructose. Adsorption of glucose to BA: chitosan conjugates was dose-dependent up to 1:1 at 35 and 42% for FPBA and FTBA respectively but the FTBA conjugates adsorbed more glucose and fructose at respective FPBA ratios. The affinity of both BA conjugates to glucose decreased with increase in BA ratio. On the other hand, the affinity of both BA conjugates for fructose decreased from ratio 1:1 to 2:1 then rose again at 3:1. Insulin release from FPBA nanoparticles (FPBAINP) and FTBA nanoparticles (FTBAINP) were both concentration-dependent within glyceamically relevant values (1–3 mg/ml glucose and 0.002 mg/ml fructose). Furthermore, the total amounts of insulin released from FPBAINP in both the media were higher than from FTBAINP. Both FPBAINP and FTBAINP have the potential for development as a glucose-selective insulin delivery system in physiological settings.

Journal Article Type Article
Journal Journal of Biomaterials Science, Polymer Edition
Print ISSN 0920-5063
Electronic ISSN 1568-5624
Publisher Taylor & Francis
Peer Reviewed Peer Reviewed
Volume 28
Issue 8
APA6 Citation Siddiqui, N. A., Billa, N., & Roberts, C. J. (in press). Multiboronic acid-conjugated chitosan scaffolds with glucose selectivity to insulin release. Journal of Biomaterials Science, Polymer Edition, 28(8), doi:10.1080/09205063.2017.1301774
DOI https://doi.org/10.1080/09205063.2017.1301774
Keywords Boronic acid, chitosan, glucose, insulin, nanoparticles
Publisher URL http://www.tandfonline.com/doi/full/10.1080/09205063.2017.1301774
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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