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Bioprinting Using Mechanically Robust Core–Shell Cell-Laden Hydrogel Strands

Mistry, Pritesh; Aied, Ahmed; Alexander, Morgan R.; Shakesheff, Kevin; Bennett, Andrew; Yang, Jing

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Authors

Pritesh Mistry

Ahmed Aied

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MORGAN ALEXANDER MORGAN.ALEXANDER@NOTTINGHAM.AC.UK
Professor of Biomedical Surfaces

Kevin Shakesheff

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JING YANG JING.YANG@NOTTINGHAM.AC.UK
Assistant Professor



Abstract

© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The strand material in extrusion-based bioprinting determines the microenvironments of the embedded cells and the initial mechanical properties of the constructs. One unmet challenge is the combination of optimal biological and mechanical properties in bioprinted constructs. Here, a novel bioprinting method that utilizes core–shell cell-laden strands with a mechanically robust shell and an extracellular matrix-like core has been developed. Cells encapsulated in the strands demonstrate high cell viability and tissue-like functions during cultivation. This process of bioprinting using core–shell strands with optimal biochemical and biomechanical properties represents a new strategy for fabricating functional human tissues and organs. (Figure presented.).

Journal Article Type Article
Acceptance Date Jan 9, 2017
Online Publication Date Feb 3, 2017
Publication Date Jun 14, 2017
Deposit Date Mar 22, 2017
Publicly Available Date Mar 22, 2017
Journal Macromolecular Bioscience
Print ISSN 1616-5187
Electronic ISSN 1616-5195
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 17
Issue 6
Article Number 1600472
DOI https://doi.org/10.1002/mabi.201600472
Keywords bioprinting; hydrogels; mechanical properties; tissue engineering
Public URL https://nottingham-repository.worktribe.com/output/847818
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/mabi.201600472/abstract?system
Additional Information This is the peer reviewed version of the following article: P. Mistry, A. Aied, M. Alexander, K. Shakesheff, A. Bennett, J. Yang, Macromol. Biosci. 2017, 1600472, which has been published in final form at doi:10.1002/mabi.201600472. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.