Bioprinting Using Mechanically Robust Core–Shell Cell-Laden Hydrogel Strands

Mistry, Pritesh; Aied, Ahmed; Alexander, Morgan R.; Shakesheff, Kevin; Bennett, Andrew; Yang, Jing

Abstract

© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim The strand material in extrusion-based bioprinting determines the microenvironments of the embedded cells and the initial mechanical properties of the constructs. One unmet challenge is the combination of optimal biological and mechanical properties in bioprinted constructs. Here, a novel bioprinting method that utilizes core–shell cell-laden strands with a mechanically robust shell and an extracellular matrix-like core has been developed. Cells encapsulated in the strands demonstrate high cell viability and tissue-like functions during cultivation. This process of bioprinting using core–shell strands with optimal biochemical and biomechanical properties represents a new strategy for fabricating functional human tissues and organs. (Figure presented.).

Citation

Mistry, P., Aied, A., Alexander, M. R., Shakesheff, K., Bennett, A., & Yang, J. (2017). Bioprinting Using Mechanically Robust Core–Shell Cell-Laden Hydrogel Strands. Macromolecular Bioscience, 17(6), Article 1600472. https://doi.org/10.1002/mabi.201600472

• Journal Article Type: Article
• Acceptance Date: Jan 9, 2017
• Online Publication Date: Feb 3, 2017
• Publication Date: Jun 14, 2017
• Deposit Date: Mar 22, 2017
• Publicly Available Date: Mar 22, 2017
• Journal: Macromolecular Bioscience
• Print ISSN: 1616-5187
• Electronic ISSN: 1616-5195
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 17
• Issue: 6
• Article Number: 1600472
• DOI: https://doi.org/10.1002/mabi.201600472
• Keywords: bioprinting; hydrogels; mechanical properties; tissue engineering
• Public URL: https://nottingham-repository.worktribe.com/output/847818
• Publisher URL: http://onlinelibrary.wiley.com/doi/10.1002/mabi.201600472/abstract?system
• Additional Information: This is the peer reviewed version of the following article: P. Mistry, A. Aied, M. Alexander, K. Shakesheff, A. Bennett, J. Yang, Macromol. Biosci. 2017, 1600472, which has been published in final form at doi:10.1002/mabi.201600472. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.