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The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis

Morandi, Elena; Tanasescu, Radu; Tarlinton, Rachael E.; Constantinescu, Cris S.; Zhang, Weiya; Tench, Christopher R.; Gran, Bruno

Authors

Elena Morandi

Radu Tanasescu

Cris S. Constantinescu

Bruno Gran



Contributors

Klemens Ruprecht
Editor

Abstract

Background:
The interaction between genetic and environmental factors is crucial to multiple sclerosis (MS) pathogenesis. Human Endogenous Retroviruses (HERVs) are endogenous viral elements of the human genome whose expression is associated with MS.
Objective:
To perform a systematic review and meta-analysis and to assess qualitative and quantitative evidence on the expression of HERV families in MS patients.
Methods:
Medline, Embase and the Cochrane Library were searched for published studies on the association of HERVs and MS. Meta-analysis was performed on the HERV-W family. Odds Ratio (OR) and 95% confidence interval (CI) were calculated for association.
Results:
43 reports were extracted (25 related to HERV-W, 13 to HERV-H, 9 to HERV-K, 5 to HRES-1 and 1 to HER-15 family). The analysis showed an association between expression of all HERV families and MS. For HERV-W, adequate data was available for meta-analysis. Results from meta-analyses of HERV-W were OR = 22.66 (95%CI 6.32 to 81.20) from 4 studies investigating MSRV/HERV-W(MS-associated retrovirus) envelope mRNA in peripheral blood mononuclear cells, OR = 44.11 (95%CI 12.95 to 150.30) from 6 studies of MSRV/ HERV-W polymerase mRNA in serum/plasma and OR = 6.00 (95%CI 3.35 to 10.74) from 4 studies of MSRV/HERV-W polymerase mRNA in CSF.

Citation

Morandi, E., Tanasescu, R., Tarlinton, R. E., Constantinescu, C. S., Zhang, W., Tench, C. R., & Gran, B. (2017). The association between human endogenous retroviruses and multiple sclerosis: a systematic review and meta-analysis. PLoS ONE, 12(2), Article e0172415. https://doi.org/10.1371/journal.pone.0172415

Journal Article Type Article
Acceptance Date Feb 3, 2017
Online Publication Date Feb 16, 2017
Publication Date Feb 16, 2017
Deposit Date Feb 17, 2017
Publicly Available Date Feb 17, 2017
Journal PLoS ONE
Electronic ISSN 1932-6203
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 12
Issue 2
Article Number e0172415
DOI https://doi.org/10.1371/journal.pone.0172415
Public URL https://nottingham-repository.worktribe.com/output/845498
Publisher URL http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0172415

Files

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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