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Age-related differences in the structural complexity of subcortical and ventricular structures

Madan, Christopher R.; Kensinger, Elizabeth A.

Authors

Elizabeth A. Kensinger



Abstract

It has been well established that the volume of several subcortical structures decreases in relation to age. Different metrics of cortical structure (e.g., volume, thickness, surface area, and gyrification) have been shown to index distinct characteristics of interindividual differences; thus, it is important to consider the relation of age to multiple structural measures. Here, we compare age-related differences in subcortical and ventricular volume to those differences revealed with a measure of structural complexity, quantified as fractal dimensionality. Across 3 large data sets, totaling nearly 900 individuals across the adult lifespan (aged 18–94 years), we found greater age-related differences in complexity than volume for the subcortical structures, particularly in the caudate and thalamus. The structural complexity of ventricular structures was not more strongly related to age than volume. These results demonstrate that considering shape-related characteristics improves sensitivity to detect age-related differences in subcortical structures.

Citation

Madan, C. R., & Kensinger, E. A. (2017). Age-related differences in the structural complexity of subcortical and ventricular structures. Neurobiology of Aging, 50, 87-95. https://doi.org/10.1016/j.neurobiolaging.2016.10.023

Journal Article Type Article
Acceptance Date Oct 20, 2016
Online Publication Date Oct 27, 2016
Publication Date 2017-02
Deposit Date Jan 15, 2018
Publicly Available Date Jan 15, 2018
Journal Neurobiology of Aging
Print ISSN 0197-4580
Electronic ISSN 1558-1497
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 50
Pages 87-95
DOI https://doi.org/10.1016/j.neurobiolaging.2016.10.023
Keywords Brain morphometry; Age; Atrophy; Fractal dimensionality; Thalamus; Hippocampus; Putamen; Ventricles
Public URL http://eprints.nottingham.ac.uk/id/eprint/49069
Publisher URL http://www.sciencedirect.com/science/article/pii/S019745801630272X
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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