Sylvia Kiconco
Recurrence risk of venous thromboembolism and hormone use in women from England: a cohort study using clinical practice research datalink
Kiconco, Sylvia; Abdul Sultan, Alyshah; Grainge, Matthew J.
Abstract
It is vital to identify people with low recurrence risk of venous thromboembolism (VTE) so as to protect them from dangers of prolonged anticoagulation therapy. Among women who develop VTE following hormone use, the evidence as to whether their risk of recurrence is low if they cease this therapy is conflicting. We investigated whether women whose initial VTE event was hormone-related have a lower risk of VTE recurrence than women whose initial event had no obvious cause (unprovoked). A cohort study utilising the Clinical Practice Research Datalink linked to Hospital Episode Statistics data from England was conducted. We selected 4170 women aged between 15 and 64 years who were diagnosed with a first VTE event between 1997 and 2011. Cox regression models were used to obtain hazard ratios (HR). Hormone users had 29% lower recurrence risk than non-users (adjusted HR = 0·71; 95% confidence interval 0·58–0·88), a relationship which existed both in women aged 15–44 years (predominantly oral contraceptive users) and those aged 45–64 years (predominantly hormone replacement therapy users). In conclusion, having a hormone-associated VTE is associated with a lower recurrence risk than one that is unprovoked after discontinuation of the hormone-containing preparation. Prolonged anticoagulation may therefore be unjustified in such women.
Citation
Kiconco, S., Abdul Sultan, A., & Grainge, M. J. (2017). Recurrence risk of venous thromboembolism and hormone use in women from England: a cohort study using clinical practice research datalink. British Journal of Haematology, 177(1), 127-135. https://doi.org/10.1111/bjh.14516
Journal Article Type | Article |
---|---|
Acceptance Date | Nov 7, 2016 |
Online Publication Date | Jan 20, 2017 |
Publication Date | Apr 30, 2017 |
Deposit Date | Feb 1, 2017 |
Publicly Available Date | Jan 21, 2018 |
Journal | British Journal of Haematology |
Print ISSN | 0007-1048 |
Electronic ISSN | 1365-2141 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 177 |
Issue | 1 |
Pages | 127-135 |
DOI | https://doi.org/10.1111/bjh.14516 |
Keywords | cohort, thromboembolism, recurrence, hormonewomen |
Public URL | https://nottingham-repository.worktribe.com/output/839677 |
Publisher URL | http://onlinelibrary.wiley.com/doi/10.1111/bjh.14516/abstract |
Contract Date | Feb 1, 2017 |
Files
figure 1.pdf
(80 Kb)
PDF
BrJHaematol revision changes in bold.pdf
(621 Kb)
PDF
You might also like
Global epidemiology of gout: prevalence, incidence and risk factors
(2015)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search