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Resting-state functional connectivity correlates of anxiety co-morbidity in major depressive disorder

Briley, P. M.; Webster, L.; Boutry, C.; Cottam, W. J.; Auer, D. P.; Liddle, P. F.; Morriss, R.

Resting-state functional connectivity correlates of anxiety co-morbidity in major depressive disorder Thumbnail


P. M. Briley

L. Webster

Research Associate

W. J. Cottam

Professor of Neuroimaging

P. F. Liddle

Professor of Psychiatry and Community Mental Health


Major depressive disorder (MDD) is frequently co-morbid with anxiety disorders. The co-morbid state has poorer functional outcomes and greater resistance to first line treatments, highlighting the need for novel treatment targets. This systematic review examined differences in resting-state brain connectivity associated with anxiety comorbidity in young- and middle-aged adults with MDD, with the aim of identifying novel targets for neuromodulation treatments, as these treatments are thought to work partly by altering dysfunctional connectivity pathways. Twenty-one studies met inclusion criteria, including a total of 1292 people with MDD. Only two studies included people with MDD and formally diagnosed co-morbid anxiety disorders; the remainder included people with MDD with dimensional anxiety measurement. The quality of most studies was judged as fair. Results were heterogeneous, partly due to a focus on a small set of connectivity relationships within individual studies. There was evidence for dysconnectivity between the amygdala and other brain networks in co-morbid anxiety, and an indication that abnormalities of default mode network connectivity may play an underappreciated role in this condition.

Journal Article Type Article
Acceptance Date May 13, 2022
Online Publication Date May 26, 2022
Publication Date Jul 1, 2022
Deposit Date Jun 8, 2022
Publicly Available Date Jun 8, 2022
Journal Neuroscience and Biobehavioral Reviews
Print ISSN 0149-7634
Electronic ISSN 1873-7528
Publisher Elsevier BV
Peer Reviewed Peer Reviewed
Volume 138
Article Number 104701
Keywords Behavioral Neuroscience; Cognitive Neuroscience; Neuropsychology and Physiological Psychology
Public URL
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