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An efficient synthesis of substituted chrysenes

Eccleshare, Lee; Selzer, Sean; Woodward, Simon

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Lee Eccleshare

Sean Selzer

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Professor of Synthetic Organic Chemistry


Substituted chrysenes have been swiftly synthesised by the 6-endo-dig cyclisation of ethynylnaphthalenes using platinum(II) chloride. Cyclisation precursors were directly prepared from commercially available 2-bromoaldehydes in a telescoped synthetic procedure involving a Cannizzaro triggered cascade and subsequent dehydration and desilylation. This short synthetic procedure allows rapid access to derivatives of biologically active molecules with useful electronic properties.


Eccleshare, L., Selzer, S., & Woodward, S. (2017). An efficient synthesis of substituted chrysenes. Tetrahedron, 58(5),

Journal Article Type Article
Acceptance Date Dec 2, 2016
Online Publication Date Dec 9, 2016
Publication Date Feb 1, 2017
Deposit Date Dec 12, 2016
Publicly Available Date Dec 12, 2016
Journal Tetrahedron
Print ISSN 0040-4020
Electronic ISSN 0040-4020
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 58
Issue 5
Keywords Polyaromatic hydrocarbon; Carbocyclisation; Microwave-assisted synthesis
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