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The impact of electrode resistance on the biogalvanic characterisation technique

Chandler, J.H.; Head, D.A.; Hubbard, Matthew E.; Neville, A.; Jayne, D.G.; Culmer, P.R.

Authors

J.H. Chandler

D.A. Head

MATTHEW HUBBARD MATTHEW.HUBBARD@NOTTINGHAM.AC.UK
Professor of Computational and Applied Mathematics

A. Neville

D.G. Jayne

P.R. Culmer



Abstract

Measurement of a tissue-specific electrical resistance may offer a discriminatory metric for evaluation of tissue health during cancer surgery. With a move toward minimally-invasive procedures, applicable contact sensing modalities must be scalable, fast and robust. A passive resistance characterisation method utilising a biogalvanic cell as an intrinsic power source has been proposed as a potentially suitable solution. Previous work has evaluated this system with results showing effective discrimination of tissue type and damage (through electroporation). However, aspects of the biogalvanic cell have been found to influence the characterisation performance, and are not currently accounted for within the system model. In particular, the electrode and salt-bridge resistance are not independently determined, leading to over-predictions of tissue resistivity.

This paper describes a more comprehensive model and characterisation scheme, with electrode parameters and salt-bridge resistivity being evaluated independently. In a generalised form, the presented model illustrates how the relative resistive contributions from the electrodes and medium relate to the existing characterisation method efficacy. We also describe experiments with physiologically relevant salt solutions (1.71, 17.1, 154 mM), used for validation and comparison. The presented model shows improved performance over the current biogalvanic measurement technique at the median conductivity. Both the proposed and extant system models become unable to predict conductivity accurately at high conductivity due to the dominance of the electrodes. The characterisation techniques have also been applied to data collected on freshly excised human colon tissue (healthy and cancerous). The findings suggest that the resistance of the cell under the test conditions is electrode dominated, leading to erroneous tissue resistance determination. Measurement optimisation strategies and the surgical applicability of the biogalvanic technique are discussed in light of these findings.

Citation

Chandler, J., Head, D., Hubbard, M. E., Neville, A., Jayne, D., & Culmer, P. (2016). The impact of electrode resistance on the biogalvanic characterisation technique. Physiological Measurement, 38(2), https://doi.org/10.1088/1361-6579/38/2/101

Journal Article Type Article
Acceptance Date Nov 11, 2016
Publication Date Dec 23, 2016
Deposit Date Feb 27, 2017
Publicly Available Date Feb 27, 2017
Journal Physiological Measurement
Print ISSN 0967-3334
Electronic ISSN 1361-6579
Publisher IOP Publishing
Peer Reviewed Peer Reviewed
Volume 38
Issue 2
DOI https://doi.org/10.1088/1361-6579/38/2/101
Public URL http://eprints.nottingham.ac.uk/id/eprint/40826
Publisher URL http://iopscience.iop.org/article/10.1088/1361-6579/38/2/101/meta
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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