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Increased liver fat and glycogen stores after consumption of high versus low glycaemic index food: a randomized crossover study

Bawden, Stephen; Stephenson, Mary; Falcone, Yirga; Lingaya, Melanie; Ciampi, Elisabetta; Hunter, Karl; Bligh, Frances; Schirra, Jörg; Taylor, Moira; Morris, Peter; MacDonald, Ian A.; Gowland, Penny; Marciani, Luca; Aithal, Guruprasad P.

Authors

Mary Stephenson

Yirga Falcone

Melanie Lingaya

Elisabetta Ciampi

Karl Hunter

Frances Bligh

Jörg Schirra

Ian A. MacDonald

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LUCA MARCIANI luca.marciani@nottingham.ac.uk
Professor of Gastrointestinal Imaging



Abstract

Aim: To investigate the acute and longer-term effects of low (LGI) versus high glycaemic index (HGI) diets on hepatic fat and glycogen accumulation and related blood measures in healthy volunteers.

Methods: Eight healthy men (age 20.1 � 0.4 years, body mass index 23.0 � 0.9 kg/m2) attended a test day before and after a 7-day macronutrient- and energy-matched HGI or LGI diet, followed by a minimum 4-week wash-out period, and then returned to repeat the intervention with the alternative diet. During test days, participants consumed either an HGI or an LGI test meal corresponding to their diet week, and liver fat [1H magnetic resonance spectroscopy (MRS)], glycogen (13C MRS) and gastric content volume (MRI) were measured. Blood samples were obtained regularly throughout the test day to assess plasma glucose and insulin levels.

Results: Plasma glucose and insulin peak values and area under the curve were significantly greater after the HGI test meal compared with the LGI test meal, as expected. Hepatic glycogen concentrations increased more after the HGI test meal (P < .05) and peak levels were significantly greater after 7 days of HGI dietary intervention compared with those at the beginning of the intervention (P < .05). Liver fat fractions increased significantly after the HGI dietary intervention compared with the LGI dietary intervention (two-way repeated-measures analysis of variance P ≤ .05).

Conclusions: Compared with an LGI diet, a 1-week HGI diet increased hepatic fat and glycogen stores. This may have important clinical relevance for dietary interventions in the prevention and management of non-alcoholic fatty liver disease.

Citation

Bawden, S., Stephenson, M., Falcone, Y., Lingaya, M., Ciampi, E., Hunter, K., …Aithal, G. P. (2017). Increased liver fat and glycogen stores after consumption of high versus low glycaemic index food: a randomized crossover study. Diabetes, Obesity and Metabolism, 19(1), 70-77. https://doi.org/10.1111/dom.12784

Journal Article Type Article
Acceptance Date Aug 23, 2016
Online Publication Date Sep 29, 2016
Publication Date 2017-01
Deposit Date Oct 5, 2016
Publicly Available Date Oct 5, 2016
Journal Diabetes, Obesity and Metabolism
Print ISSN 1462-8902
Electronic ISSN 1463-1326
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 19
Issue 1
Pages 70-77
DOI https://doi.org/10.1111/dom.12784
Keywords Dietary intervention, Fatty liver, Glycaemic control, Liver, Randomised trial
Public URL http://eprints.nottingham.ac.uk/id/eprint/37368
Publisher URL http://onlinelibrary.wiley.com/doi/10.1111/dom.12784/abstract;jsessionid=C0EBDCF01CB2965D4AC73DF1CA369C44.f01t01
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf
Additional Information This is the peer reviewed version of the following article: Bawden S , Stephenson M , Falcone Y , Lingaya M , Ciampi E , Hunter K , Bligh F , Schirra J , Taylor M , Morris P , Macdonald I , Gowland P , Marciani L and Aithal G . Increased liver fat and glycogen stores after consumption of high versus low glycaemic index food: A randomized crossover study, Diabetes Obes Metab 2016, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1111/dom.12784/abstract. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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