Nusrat Sharmin
Compositional dependency on dissolution rate and cytocompatibility of phosphate-based glasses: effect of B2O3 and Fe2O3 addition
Sharmin, Nusrat; Gu, Fu; Ahmed, Ifty; Parsons, Andrew J
Authors
Fu Gu
Professor IFTY AHMED ifty.ahmed@nottingham.ac.uk
PROFESSOR OF MATERIALS SCIENCE AND ENGINEERING
Dr Andrew Parsons ANDREW.PARSONS@NOTTINGHAM.AC.UK
SENIOR RESEARCH FELLOW
Abstract
The unique property of phosphate-based glasses and fibres to be completely dissolved in aqueous media is largely dependent on the glass composition. This article focuses on investigating the effect of replacing Na2O with 3 and 5 mol% Fe2O3 on cytocompatibility, thermal and dissolution properties of P2O5–CaO–Na2O–MgO–B2O3 glass system, where P2O5 content was fixed at 45 mol%. The effect of increasing Fe2O3 from 3 to 5 mol% on P2O5–CaO–Na2O–MgO glasses was also evaluated. The glass transition temperature, onset of crystallisation temperature and liquidus temperature were found to decrease with increasing Fe2O3 content and the addition of B2O3, while the thermal expansion values were found to decrease. The density of the glasses decreased with increasing Fe2O3 content. However, an increase in the density was observed by the addition of 5 mol% B2O3. The dissolution properties and mode of bulk glass and fibres were also examined which were found to decrease with increasing B2O3 and Fe2O3. However, it was found that the dissolution properties of the glasses containing both B2O3 and Fe2O3 were lower than only Fe2O3 containing glasses. The in vitro cell culture studies using human osteoblast like (MG63) cell lines revealed that the glasses containing both B2O3 and Fe2O3 maintained and showed higher cell viability as compared to the only Fe2O3 containing glasses. Glasses containing both B2O3 and Fe2O3 showed a pronounced effect on the dissolution rate of the glasses, which eventually improved the cytocompatibility properties of the glasses investigated.
Citation
Sharmin, N., Gu, F., Ahmed, I., & Parsons, A. J. (2017). Compositional dependency on dissolution rate and cytocompatibility of phosphate-based glasses: effect of B2O3 and Fe2O3 addition. Journal of Tissue Engineering, 8, 204173141774445. https://doi.org/10.1177/2041731417744454
Journal Article Type | Article |
---|---|
Acceptance Date | Nov 6, 2017 |
Online Publication Date | Dec 11, 2017 |
Publication Date | 2017-01 |
Deposit Date | Feb 5, 2018 |
Publicly Available Date | Feb 5, 2018 |
Journal | Journal of Tissue Engineering |
Print ISSN | 2041-7314 |
Electronic ISSN | 2041-7314 |
Publisher | SAGE Publications |
Peer Reviewed | Peer Reviewed |
Volume | 8 |
Pages | 204173141774445 |
DOI | https://doi.org/10.1177/2041731417744454 |
Keywords | Phosphate-based glasses, dissolution properties, thermal properties, fibre dissolution mode, cytocompatibility |
Public URL | https://nottingham-repository.worktribe.com/output/830926 |
Publisher URL | http://journals.sagepub.com/doi/10.1177/2041731417744454 |
Contract Date | Feb 5, 2018 |
Files
Compositional dependency on dissolution rate and cytocompatibility of phosphate-based glasses_ Effect of B2O3 and Fe2O3 addition.pdf
(836 Kb)
PDF
Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
You might also like
Reinforcing fibres
(2023)
Book Chapter
L-DOPA coating improved phosphate glass fibre strength and fibre/matrix interface
(2022)
Journal Article
Controlling mass loss from RTM6 epoxy resin under simulated vacuum infusion conditions
(2022)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2025
Advanced Search