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Long-term coding of personal and universal associations underlying the memory web in the human brain

De Falco, Emanuela; Ison, Matias J.; Fried, Itzhak; Quian Quiroga, Rodrigo

Authors

Emanuela De Falco

Itzhak Fried

Rodrigo Quian Quiroga



Abstract

Neurons in the medial temporal lobe (MTL), a critical area for declarative memory, have been shown to change their tuning in associative learning tasks. Yet, it is unclear how durable these neuronal representations are and if they outlast the execution of the task. To address this issue, we studied the responses of MTL neurons in neurosurgical patients to known concepts (people and places). Using association scores provided by the patients and a web-based metric, here we show that whenever MTL neurons respond to more than one concept, these concepts are typically related. Furthermore, the degree of association between concepts could be successfully predicted based on the neurons’ response patterns. These results provide evidence for a long-term involvement of MTL neurons in the representation of durable associations, a hallmark of human declarative memory.

Citation

De Falco, E., Ison, M. J., Fried, I., & Quian Quiroga, R. (2016). Long-term coding of personal and universal associations underlying the memory web in the human brain. Nature Communications, 7, https://doi.org/10.1038/ncomms13408

Journal Article Type Article
Acceptance Date Sep 30, 2016
Publication Date Nov 15, 2016
Deposit Date Jul 31, 2017
Publicly Available Date Jul 31, 2017
Journal Nature Communications
Electronic ISSN 2041-1723
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 7
Article Number 13408
DOI https://doi.org/10.1038/ncomms13408
Public URL http://eprints.nottingham.ac.uk/id/eprint/44487
Publisher URL https://doi.org/10.1038/ncomms13408
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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