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Encoding of long-term associations through neural unitization in the human medial temporal lobe

Rey, Hernan G.; De Falco, Emanuela; Ison, Matias J.; Valentin, Antonio; Alarcon, Gonzalo; Selway, Richard; Richardson, Mark P.; Quian Quiroga, Rodrigo

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Authors

Hernan G. Rey

Emanuela De Falco

Antonio Valentin

Gonzalo Alarcon

Richard Selway

Mark P. Richardson

Rodrigo Quian Quiroga



Abstract

© 2018, The Author(s). Besides decades of research showing the role of the medial temporal lobe (MTL) in memory and the encoding of associations, the neural substrates underlying these functions remain unknown. We identified single neurons in the human MTL that responded to multiple and, in most cases, associated stimuli. We observed that most of these neurons exhibit no differences in their spike and local field potential (LFP) activity associated with the individual response-eliciting stimuli. In addition, LFP responses in the theta band preceded single neuron responses by ~70 ms, with the single trial phase providing fine tuning of the spike response onset. We postulate that the finding of similar neuronal responses to associated items provides a simple and flexible way of encoding memories in the human MTL, increasing the effective capacity for memory storage and successful retrieval.

Journal Article Type Article
Acceptance Date Sep 29, 2018
Online Publication Date Oct 22, 2018
Publication Date Dec 1, 2018
Deposit Date Dec 4, 2018
Publicly Available Date Dec 4, 2018
Journal Nature Communications
Electronic ISSN 2041-1723
Publisher Nature Publishing Group
Peer Reviewed Peer Reviewed
Volume 9
Issue 1
Article Number 4372
DOI https://doi.org/10.1038/s41467-018-06870-2
Keywords General Biochemistry, Genetics and Molecular Biology; General Physics and Astronomy; General Chemistry
Public URL https://nottingham-repository.worktribe.com/output/1363240
Publisher URL https://www.nature.com/articles/s41467-018-06870-2

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