The future of multiple sclerosis treatments

Coclitu, Catalina; Constantinescu, Cris S.; Tanasescu, Radu

Abstract

Introduction. There are not many conditions in which the last few decades have brought such a major change in the landscape of treatments as is the case of multiple sclerosis (MS). A number of disease modifying treatments (DMTs) are presently available for the treatment of the inflammatory phase of this disabling disease; however, the need for treating neurodegeneration and halting the progression of disability is still unmet.

Areas covered: In this paper we review the available information on existing and emerging DMTs and we discuss their place within the context of different treatment strategies in MS.

Expert Commentary: The future of MS treatments should include the development of new treatment strategies tackling disease progression, together with a better understanding of the side-effects and the best sequential strategy of implementation of available and emerging drugs.

Citation

Coclitu, C., Constantinescu, C. S., & Tanasescu, R. (in press). The future of multiple sclerosis treatments. Expert Review of Neurotherapeutics, 16(12), https://doi.org/10.1080/14737175.2016.1243056

• Journal Article Type: Article
• Acceptance Date: Sep 27, 2016
• Online Publication Date: Oct 21, 2016
• Deposit Date: Oct 19, 2016
• Publicly Available Date: Oct 21, 2016
• Journal: Expert Review of Neurotherapeutics
• Print ISSN: 1473-7175
• Electronic ISSN: 1744-8360
• Publisher: Taylor & Francis Open
• Peer Reviewed: Peer Reviewed
• Volume: 16
• Issue: 12
• DOI: https://doi.org/10.1080/14737175.2016.1243056
• Keywords: Multiple sclerosis, Immunomodulation, Monoclonal antibodies, Remyelination, Repurposing
• Public URL: https://nottingham-repository.worktribe.com/output/822232
• Publisher URL: http://www.tandfonline.com/doi/abs/10.1080/14737175.2016.1243056?journalCode=iern20