Assessment of a rapid liquid-based cytology method for measuring sputum cell counts

Martin, M.J.; Lee, H.; Meakin, G.; Green, A.; Simms, R.L.; Reynolds, C.; Winters, S.; Shaw, Dominick E.; Soomro, Irshad N.; Harrison, Timothy W.

Abstract

Differential sputum cell counting is not widely available despite proven clinical utility in the management of asthma. We compared eosinophil counts obtained using liquid-based cytology (LBC), a routine histopathological processing method, and the current standard method. Eosinophil counts obtained using LBC were a strong predictor of sputum eosinophilia (≥3%) determined by the standard method suggesting LBC could be used in the management of asthma.

Citation

Martin, M., Lee, H., Meakin, G., Green, A., Simms, R., Reynolds, C., Winters, S., Shaw, D. E., Soomro, I. N., & Harrison, T. W. (in press). Assessment of a rapid liquid-based cytology method for measuring sputum cell counts. Thorax, https://doi.org/10.1136/thoraxjnl-2016-208817

• Journal Article Type: Article
• Acceptance Date: Jul 6, 2016
• Online Publication Date: Aug 8, 2016
• Deposit Date: Nov 1, 2016
• Publicly Available Date: Nov 1, 2016
• Journal: Thorax
• Print ISSN: 0040-6376
• Electronic ISSN: 1468-3296
• Publisher: BMJ Publishing Group
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1136/thoraxjnl-2016-208817
• Public URL: https://nottingham-repository.worktribe.com/output/806268
• Publisher URL: http://thorax.bmj.com/content/early/2016/08/08/thoraxjnl-2016-208817.abstract
• Contract Date: Nov 1, 2016