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Environmental chemicals impact dog semen quality in vitro and may be associated with a temporal decline in sperm motility and increased cryptorchidism

Lea, Richard G.; Byers, Andrew S.; Sumner, Rebecca N.; Rhind, Stewart M.; Zhang, Zulin; Freeman, Sarah L.; Moxon, Rachel; Richardson, Holly M.; Green, Martin; Craigon, Jim; England, Gary C.W.

Authors

RICHARD LEA richard.lea@nottingham.ac.uk
Associate Professor and Reader Inreproductive Biology

Andrew S. Byers

Rebecca N. Sumner

Stewart M. Rhind

Zulin Zhang

SARAH FREEMAN sarah.freeman@nottingham.ac.uk
Professor of Veterinary Surgery

Rachel Moxon

Holly M. Richardson

MARTIN GREEN martin.green@nottingham.ac.uk
Professor of Cattle Health & Epidemiology

Jim Craigon

Gary C.W. England



Abstract

Adverse temporal trends in human semen quality and cryptorchidism in infants have been associated with exposure to environmental chemicals (ECs) during development. Here we report that a population of breeding dogs exhibit a 26 year (1988–2014) decline in sperm quality and a concurrent increased incidence of cryptorchidism in male offspring (1995–2014). A decline in the number of males born relative to the number of females was also observed. ECs, including diethylhexyl phthalate (DEHP) and polychlorinated biphenyl 153 (PCB153), were detected in adult dog testes and commercial dog foods at concentrations reported to perturb reproductive function in other species. Testicular concentrations of DEHP and PCB153 perturbed sperm viability, motility and DNA integrity in vitro but did not affect LH stimulated testosterone secretion from adult testis explants. The direct effects of chemicals on sperm may therefore contribute to the decline in canine semen quality that parallels that reported in the human.

Citation

Lea, R. G., Byers, A. S., Sumner, R. N., Rhind, S. M., Zhang, Z., Freeman, S. L., …England, G. C. (2016). Environmental chemicals impact dog semen quality in vitro and may be associated with a temporal decline in sperm motility and increased cryptorchidism. Scientific Reports, 6(1), https://doi.org/10.1038/srep31281

Journal Article Type Article
Acceptance Date Jul 15, 2016
Online Publication Date Aug 9, 2016
Publication Date 2016-11
Deposit Date Oct 18, 2016
Publicly Available Date Oct 18, 2016
Journal Scientific Reports
Print ISSN 2045-2322
Electronic ISSN 2045-2322
Publisher Nature Research
Peer Reviewed Peer Reviewed
Volume 6
Issue 1
Article Number 31281
DOI https://doi.org/10.1038/srep31281
Public URL http://eprints.nottingham.ac.uk/id/eprint/37649
Publisher URL http://www.nature.com/articles/srep31281
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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