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How Clinically Relevant Are Treatment Comparisons of Topical Calcineurin Inhibitor Trials for Atopic Eczema?

Wilkes, Sally R.; Nankervis, Helen; Tavernier, Elsa; Maruani, Annabel; Williams, Hywel C.

Authors

Sally R. Wilkes

Helen Nankervis

Elsa Tavernier

Annabel Maruani

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HYWEL WILLIAMS hywel.williams@nottingham.ac.uk
Professor of Dermato-Epidemiology



Abstract

We sought to explore the architecture of trials of calcineurin inhibitors for atopic eczema to document the extent to which comparisons with active treatments such as topical corticosteroids (TCS) might have been included or avoided. We identified all eligible randomized controlled trials (RCTs) using the Global Resource for EczemA Trials database. Network plots were produced where the nodes represented a treatment type and the lines between the nodes represented the number of trials or participants that were involved in the various treatment comparisons. A total of 174 RCTs for atopic eczema treatments were identified where pimecrolimus, tacrolimus or topical corticosteroids were compared with another intervention or a vehicle/emollient. Of 39 trials involving pimecrolimus and of 41 trials involving tacrolimus, 8 (20.5%) and 13 (31.7%) respectively made comparisons with topical corticosteroids, and 25 (64.1%) and 15 (36.6%) respectively were vehicle-controlled studies. The high rate of comparisons with vehicle controls in RCTs assessing the efficacy of pimecrolimus or tacrolimus long after efficacy had been established is a matter of concern. Active comparators (mild TCS for pimecrolimus and moderate to potent TCS for tacrolimus) are best placed to inform how topical calcineurin inhibitors compare to established clinical practice.

Citation

Wilkes, S. R., Nankervis, H., Tavernier, E., Maruani, A., & Williams, H. C. (2016). How Clinically Relevant Are Treatment Comparisons of Topical Calcineurin Inhibitor Trials for Atopic Eczema?. Journal of Investigative Dermatology, 136(10), 1944-1949. https://doi.org/10.1016/j.jid.2016.05.104

Journal Article Type Article
Acceptance Date May 23, 2016
Online Publication Date Jul 20, 2016
Publication Date 2016-10
Deposit Date Jul 10, 2016
Publicly Available Date Jul 20, 2016
Journal Journal of Investigative Dermatology
Print ISSN 0022-202X
Electronic ISSN 1523-1747
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 136
Issue 10
Pages 1944-1949
DOI https://doi.org/10.1016/j.jid.2016.05.104
Keywords Atopic eczema; Topical corticosteroids; Calcineurin inhibitors; Randomised clinical trial; Network geometry
Public URL http://eprints.nottingham.ac.uk/id/eprint/33835
Publisher URL http://www.sciencedirect.com/science/article/pii/S0022202X16313331
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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