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Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease

Selvarajah, Senthooran; Todd, Ian; Tighe, Patrick J.; John, Michelle; Bolton, Charlotte E.; Harrison, Timothy W.; Fairclough, Lucy C.


Senthooran Selvarajah

Ian Todd

Professor of Molecular Immunology

Michelle John

Professor of Asthma and Respiratory Medicine


Inflammatory biomarkers, including cytokines, are associated with COPD, but the association of particular circulating cytokines with systemic pathology remains equivocal. To investigate this, we developed a protein microarray system to detect multiple cytokines in small volumes of serum. Fourteen cytokines were measured in serum from never-smokers, ex-smokers, current smokers, and COPD patients (GOLD stages 1–3). Certain individual circulating cytokines (particularly TNFa and IL-1b) were significantly elevated in concentration in the serum of particular COPD patients (and some current/ex-smokers without COPD) and may serve as markers of particularly significant systemic inflammation. However, numerous circulating cytokines were raised such that their combined, but not individual, elevation was significantly associated with severity of disease, and these may be further indicators of, and contributors to, the systemic inflammatory manifestations of COPD. The coelevation of numerous circulating cytokines in COPD is consistent with the insidious development, chronic nature, and systemic comorbidities of the disease.


Selvarajah, S., Todd, I., Tighe, P. J., John, M., Bolton, C. E., Harrison, T. W., & Fairclough, L. C. (2016). Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease. Mediators of Inflammation, 2016, 1-9.

Journal Article Type Article
Acceptance Date Jun 23, 2016
Online Publication Date Jun 23, 2016
Publication Date 2016
Deposit Date Sep 23, 2016
Publicly Available Date Sep 23, 2016
Journal Mediators of Inflammation
Print ISSN 0962-9351
Electronic ISSN 1466-1861
Publisher Hindawi Publishing Corporation
Peer Reviewed Peer Reviewed
Volume 2016
Article Number 3604842
Pages 1-9
Public URL
Publisher URL


3604842.pdf (2 Mb)

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