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Dynamic regulation of auxin oxidase and conjugating enzymes AtDAO1 and GH3 modulates auxin homeostasis

Mellor, Nathan L.; Band, Leah. R.; P?n?�k, Ale�; Novak, Ondrej; Rashed, Afaf; Holman, Tara; Wilson, Michael H.; Voss, Ute; Bishopp, Antony; King, John R.; Ljung, Karin; Bennett, Malcolm J.; Owen, Markus R.

Authors

LEAH BAND leah.band@nottingham.ac.uk
Professor of Mathematical Biology

Ale� P?n?�k

Ondrej Novak

Afaf Rashed

Tara Holman

UTE VOSS ute.voss@nottingham.ac.uk
Assistant Professor

JOHN KING JOHN.KING@NOTTINGHAM.AC.UK
Professor of Theoretical Mechanics

Karin Ljung



Abstract

Auxin is a key hormone regulating plant growth and development. We combine experiments and mathematical modeling to reveal how auxin levels are maintained via feedback regulation of genes encoding key metabolic enzymes. We describe how regulation of auxin oxidation via transcriptional control of Arabidopsis thaliana gene DIOXYGENASE FOR AUXIN OXIDATION 1 (AtDAO1) expression is important at low to normal auxin concentrations. In contrast, higher auxin levels lead to increased Gretchen Hagen3 expression and auxin conjugation. Integrating this understanding into a multicellular model of root auxin dynamics successfully predicts that the dao1-1 mutant has an auxin-dependent longer root hair phenotype. Our findings reveal the importance of auxin homeostasis to maintain this hormone at optimal levels for plant growth and development.

Citation

Mellor, N. L., Band, L. R., Pěnčík, A., Novak, O., Rashed, A., Holman, T., …Owen, M. R. (2016). Dynamic regulation of auxin oxidase and conjugating enzymes AtDAO1 and GH3 modulates auxin homeostasis. Proceedings of the National Academy of Sciences, 113(39), 11022-11027. https://doi.org/10.1073/pnas.1604458113

Journal Article Type Article
Acceptance Date Jul 29, 2016
Online Publication Date Sep 20, 2016
Publication Date Sep 27, 2016
Deposit Date Sep 9, 2016
Publicly Available Date Mar 28, 2024
Journal Proceedings of the National Academy of Sciences
Print ISSN 0027-8424
Electronic ISSN 1091-6490
Publisher National Academy of Sciences
Peer Reviewed Peer Reviewed
Volume 113
Issue 39
Pages 11022-11027
DOI https://doi.org/10.1073/pnas.1604458113
Keywords Hormone Regulation, Auxin, Metabolism, Homeostasis, Arabidopsis Thaliana
Public URL https://nottingham-repository.worktribe.com/output/798478
Publisher URL http://www.pnas.org/content/113/39/11022

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