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Biomarkers of liver fibrosis

Morling, Joanne R.; Guha, Indra Neil

Authors

JOANNE MORLING JOANNE.MORLING@NOTTINGHAM.AC.UK
Clinician Scientist Fellowin Public Health

NEIL GUHA neil.guha@nottingham.ac.uk
Professor of Hepatology



Abstract

Currently the only accepted method (gold standard) for the diagnosis of the fibrotic stages of chronic liver disease (CLD) is liver biopsy, to allow histological assessment. Liver biopsy is an invasive investigation associated with a range adverse events (e.g. pain, haemorrhage) limiting its serial usage in clinical practice. Additionally, its use is further reduced by sampling error and because histology is in effect a surrogate for clinical outcomes.
Over recent years, alternative non-invasive biomarkers for the diagnosis of liver fibrosis have been developed. Initially developed in chronic viral hepatitis these have since seen their use expanded to include all aetiologies of CLD. Such markers can be divided into indirect ‘simple’ markers (e.g. transaminases, gamma-glutamyl transferase, platelet count), direct ‘complex’ markers (e.g. procollagen peptides I/III, Type IV collagen), cytokines (e.g. interleukin-10, transforming growth factor alpha) and imaging. Here, we discuss the clinical utility, limitations and development of non-invasive biomarkers in their use as diagnostic and prognostic tests.

Citation

Morling, J. R., & Guha, I. N. (in press). Biomarkers of liver fibrosis. Clinical Liver Disease, 7(6), https://doi.org/10.1002/cld.555

Journal Article Type Article
Acceptance Date Mar 28, 2016
Online Publication Date Jun 28, 2016
Deposit Date Jun 29, 2016
Publicly Available Date Jun 29, 2016
Journal Clinical Liver Disease
Electronic ISSN 2046-2484
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 7
Issue 6
DOI https://doi.org/10.1002/cld.555
Public URL http://eprints.nottingham.ac.uk/id/eprint/34456
Publisher URL http://onlinelibrary.wiley.com/doi/10.1002/cld.555/full
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information This is the peer reviewed version of the following article: Morling, Joanne R. and Guha, Indra N. Biomarkers of liver fibrosis. Clinical Liver Disease Vol. 7, issue 6: 139-142. doi: 10.1002/cld.555 which has been published in final form at http://onlinelibrary.wi...oi/10.1002/cld.555/full
This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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