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Amygdala subnuclei response and connectivity during emotional processing

Hrybouski, Stanislau; Aghamohammadi-Sereshki, Arash; Madan, Christopher R.; Shafer, Andrea T.; Baron, Corey A.; Seres, Peter; Beaulieu, Christian; Olsen, Fraser; Malykhin, Nikolai V.

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Stanislau Hrybouski

Arash Aghamohammadi-Sereshki

Christopher R. Madan

Andrea T. Shafer

Corey A. Baron

Peter Seres

Christian Beaulieu

Fraser Olsen

Nikolai V. Malykhin


The involvement of the human amygdala in emotion-related processing has been studied using functional magnetic resonance imaging (fMRI) for many years. However, despite the amygdala being comprised of several subnuclei, most studies investigated the role of the entire amygdala in processing of emotions. Here we combined a novel anatomical tracing protocol with event-related high-resolution fMRI acquisition to study the responsiveness of the amygdala subnuclei to negative emotional stimuli and to examine intra-amygdala functional connectivity. The greatest sensitivity to the negative emotional stimuli was observed in the centromedial amygdala, where the hemodynamic response amplitude elicited by the negative emotional stimuli was greater and peaked later than for neutral stimuli. Connectivity patterns converge with extant findings in animals, such that the centromedial amygdala was more connected with the nuclei of the basal amygdala than with the lateral amygdala. Current findings provide evidence of functional specialization within the human amygdala.


Hrybouski, S., Aghamohammadi-Sereshki, A., Madan, C. R., Shafer, A. T., Baron, C. A., Seres, P., …Malykhin, N. V. (2016). Amygdala subnuclei response and connectivity during emotional processing. NeuroImage, 133,

Journal Article Type Article
Acceptance Date Feb 18, 2016
Online Publication Date Feb 27, 2016
Publication Date Jun 30, 2016
Deposit Date Jan 15, 2018
Publicly Available Date Jan 15, 2018
Journal NeuroImage
Print ISSN 1053-8119
Electronic ISSN 1095-9572
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 133
Keywords High-resolution fMRI; Amygdala subnuclei; Amygdala connectivity; Emotions
Public URL
Publisher URL


High_RES_Amy_Manuscript.pdf (6.7 Mb)

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