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Associations of limbic-affective brain activity and severity of ongoing chronic arthritis pain are explained by trait anxiety

Cottam, William J.; Condon, Laura; Alshuft, Hamza; Reckziegel, Diane; Auer, Dorothee P.

Authors

Hamza Alshuft

Diane Reckziegel

Dorothee P. Auer



Abstract

Functional magnetic resonance imaging studies (fMRI) have transformed our understanding of central processing of evoked pain but the typically used block and event-related designs are not best suited to the study of ongoing pain. Here we used arterial spin labelling (ASL) for cerebral blood flow mapping to characterise the neural correlates of perceived intensity of osteoarthritis (OA) pain and its interrelation with negative affect. Twenty-six patients with painful knee OA and twenty-seven healthy controls underwent pain phenotyping and ASL MRI at 3T. Intensity of OA pain correlated positively with blood flow in the anterior mid-cingulate cortex (aMCC), subgenual cingulate cortex (sgACC), bilateral hippocampi, bilateral amygdala, left central operculum, mid-insula, putamen and the brainstem. Additional control for trait anxiety scores reduced the pain-CBF association to the aMCC, whilst pain catastrophizing scores only explained some of the limbic correlations. In conclusion, we found that neural correlates of reported intensity of ongoing chronic pain intensity mapped to limbic-affective circuits, and that the association pattern apart from aMCC was explained by trait anxiety thus highlighting the importance of aversiveness in the experience of clinical pain.

Citation

Cottam, W. J., Condon, L., Alshuft, H., Reckziegel, D., & Auer, D. P. (in press). Associations of limbic-affective brain activity and severity of ongoing chronic arthritis pain are explained by trait anxiety. NeuroImage: Clinical, 12, https://doi.org/10.1016/j.nicl.2016.06.022

Journal Article Type Article
Acceptance Date Jun 30, 2016
Online Publication Date Jul 1, 2016
Deposit Date Jul 29, 2016
Publicly Available Date Jul 29, 2016
Journal NeuroImage: Clinical
Electronic ISSN 2213-1582
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 12
DOI https://doi.org/10.1016/j.nicl.2016.06.022
Public URL http://eprints.nottingham.ac.uk/id/eprint/35565
Publisher URL http://dx.doi.org/10.1016/j.nicl.2016.06.022
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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