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α-chloralose poisoning in a cat

Grau-Roma, Llorenç; Stephens, Adam; Wessmann, Annette; Carmichael, Nick; de Brot, Simone


Llorenç Grau-Roma

Adam Stephens

Annette Wessmann

Nick Carmichael

Simone de Brot


A five-year-old domestic cat with acute unexplainable neurological signs was presented for postmortem examination. Clinically, the cat showed an acute onset of ataxia, depressed mentation and continuous twitching/ seizure activity in the morning after having been outside overnight. Despite immediate treatment, the cat# progressed within 24 hours to a comatose state, opisthotonus and severe miosis unresponsive to light. Given a poor prognosis, euthanasia was elected. Gross findings were disappointing and consisted of a nonspecific lung oedema and congested lungs and spleen. Surprisingly, within the stomach and intestines, fragments of cockshafers were found. Histological examination confirmed the gross findings and additionally showed evidence of mild brain oedema, but failed to identify a cause for the severe clinical signs. In a final attempt to solve the case, a urine sample was tested for toxic substances and it was found to contain a significant amount of α-chloralose. This finding was unexpected.


Grau-Roma, L., Stephens, A., Wessmann, A., Carmichael, N., & de Brot, S. (2016). α-chloralose poisoning in a cat.

Journal Article Type Article
Acceptance Date Apr 24, 2016
Publication Date May 17, 2016
Deposit Date Oct 31, 2016
Publicly Available Date Oct 31, 2016
Journal Veterinary Record Case Reports
Electronic ISSN 2052-6121
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 4
Issue e00031
Public URL
Publisher URL
Copyright Statement Copyright information regarding this work can be found at the following address:


AC poisoning cat_Graur-Roma et al._2016_R1_accepted version for eprint_31.10.2016.pdf (438 Kb)

Copyright Statement
Copyright information regarding this work can be found at the following address:

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